Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

PHASE2

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-05-01

Study Completion Date

2026-04-01

Brief Summary

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Scabies is highly contagious,pruritic infestation of skin.Various treatment modalities have been used but search for ideal scabicide is ongoing.we wnt to coduct this study to compare the outcome of permethrin verses ivermectin in children for treatment of scabies .This randomized clinical trial will be done in children hospital lahore for 12 months.Sample size of 90 cases;30 in each group will be included through non probability consecutive sampling.Then patient will be randomly divided into 3 groups.In group A patient will be given 5% permethrin topical application to whole body single application. In Group B ,patients will be given topical permethrin for twice application 24 hrs appart ,In group C patients will be given Tablet Ivermectin single dose 200microgram/kg.Then patients will be examined after 2 weeks and 4 weeks for no of lesions and pruritis and cure will be labeled.All this information will be recorded on performa .Data will be entered and analysed by using SPSS version 26.Three groups will be compared for cure by using chi-square test.P value less than and equal to 0.05 will be considered as significant.

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Detailed Description

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Conditions

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Scabies

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Group A

Group A will be given Permethrin

Group Type EXPERIMENTAL

Permethrin Cream, 5%

Intervention Type DRUG

Permethrin 5% cream will be given as a single application

Group B

Group B will be given Permethrin 5% cream twice application

Group Type EXPERIMENTAL

Permethrin Cream, 5%

Intervention Type DRUG

Permethrin Cream will be given as twice application

Group C

Group C will be given Tab Ivermectin

Group Type EXPERIMENTAL

Ivermectin 200 µg/kg

Intervention Type DRUG

Group C will be given Tab Ivermectin

Interventions

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Permethrin Cream, 5%

Permethrin 5% cream will be given as a single application

Intervention Type DRUG

Permethrin Cream, 5%

Permethrin Cream will be given as twice application

Intervention Type DRUG

Ivermectin 200 µg/kg

Group C will be given Tab Ivermectin

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Age 6-15
* Both genders
* Diagnosed with scabies (as per operational definition)

Exclusion Criteria

* Children with recurrent scabies on medical record
* Known allergy to ivermectin or permethrin.
* Widespread eczema or impetigo.
* Liver dysfunction or renal failure

Minimum Eligible Age

6 Years

Maximum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No