Place of Hygiene in Scabies's Treatment in Populations in Precarious Situations

NCT ID: NCT05271968

Last Updated: 2022-03-09

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 218 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-04-30
• Study Completion Date: 2022-06-30

Brief Summary

Scabies is a parasitic pathology contracted mainly through human contamination. It is caused by a parasite (Sarcoptes Scabiei var. hominis) which lodges into the top layer of the epidermis creating a burrow, which can measure 5 mm to 15 mm, where the female lays her eggs.

After 4-6 weeks the patient develops an allergic reaction to the presence of mite proteins and feces in the scabies burrow, causing intense itch and rash. The usual adult form, called common scabies, is characterized by this nocturnal pruritus, and typical and/or atypical lesions. The typical lesions are the vesicle (translucent vesicle on an erythematous base), the scabious burrow (due to the tunnel dug by the female in the stratum), and the papulo- nodule -nodular scabious (red/brown infiltrated on palpation, predominantly on the male genital areas). They predominate in certain regions: the interdigital region of the hands, the anterior face of the wrists, the external face of the elbows, the axillary region, the areolas, the nipples, the umbilical region, the male external genitalia, the buttock region, the face inner thighs.

Scabies occurs worldwide. However, studies have shown a greater prevalence among populations that do not have access to common hygiene measures: poor, young children and elderly in resource -poor communities, migrant, homeless populations, etc. The "Baudelaire outpatient clinic" (BOPC) at St Antoine hospital in Paris offers general medicine consultations. It has the particularity of offering a so called "Permanent d'Accès Aux Soins" service that allowed any person without health assurance to have access to a general practitioner and treatment, free of charge and help to recover its social rights. Consequently, more than 60% of the patients encountered at the consultation of the BOPC are in a precarious situation.

Usually, poor patients with scabies may be offered a shower and clean clothes at the BOPC Therefore it seemed to us the ideal place to evaluate a treatment's scabies in this population including the hygiene treatment.

Detailed Description

The objective of our study is to evaluate the superiority of a global management of scabies compared to a conventional treatment.

The classic treatment recommended is the prescription of an oral drug, Ivermectin to be taken two times at one or 2 weeks interval. And recommendations on the need to change the clothes and the linen of the bedding the following day after taking the drug, washing them at more than 50° as well as all the clothes three days before are explained. The first course of oral treatment is swallowed at the BOPC, while the second course is given to be swallowed one week later.

For the interventional arm, the first course of the oral treatment has also to be swallowed at the BOPC but the patient will have to come back the following day to take a shower at the BOPC and will receive new clothes. The second course will be given, but the patient will have to come back the following day of the second course to take a shower at the BOPC and to receive again new clothes.

We will compare the number of patients cured in the interventional arm versus the control arm at D28.

Conditions

Scabies

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Control

Standard Care : The classic treatment recommended is the prescription of an oral drug, Ivermectin to be taken two times at one or 2 weeks interval. And recommendations on the need to change the clothes and the linen of the bedding the following day after taking the drug, washing them at more than 50° as well as all the clothes three days before are explained. The first course of oral treatment is swallowed at the BOPC, while the second course is given to be swallowed one week later.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Intervention

Patients in this interventional arm will come back to BOPC the following day after intake the treatment (D1 and D8) to take a shower and to receive again new clothes

Group Type: EXPERIMENTAL

Global management of scabies

Intervention Type: PROCEDURE

For the interventional arm, the first course of the oral treatment has also to be swallowed at the BOPC service, but the patient will have to come back the following day to take a shower at the BOPC service and will receive new clothes.

The second course will be given, but the patient will have to come back the following day of the second course to take a shower at the BOPC service and to receive again new clothes

Interventions

Global management of scabies

For the interventional arm, the first course of the oral treatment has also to be swallowed at the BOPC service, but the patient will have to come back the following day to take a shower at the BOPC service and will receive new clothes.

The second course will be given, but the patient will have to come back the following day of the second course to take a shower at the BOPC service and to receive again new clothes

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• Patient seen in consultation at the outpatient clinic, diagnosed with non-hyperkeratotic scabies.
• Living on the streets or without access to body care.
• Having received information on the protocol and having signed consent

Exclusion Criteria

• Patient alcoholic on the day of the consultation
• Medical history fo psychiatric disease , severe somatic comorbidity, allergy to Ivermectin, pregnant woman
• Patient not understanding the on-site management (shower, change of clothes, taking the first dose of the drug on site)
• Non-communicating patient
• Hyperkeratotic or impetiginized scabies
• Patients not reachable by phone
• Patient having been treated for scabies less than 45 days before
• Patients under guardianship / curator ship or adults and subject to another protective measure.
• Pregnant and breastfeeding women
• Persons deprived of liberty by judicial and administrative decision

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Bacha Kaoutar

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Locations

Hopital Saint Antoine - Polyclinique Beaudelaire

Paris, Ap-hp, France

Countries

France

Central Contacts

Bacha Kaoutar

Role: CONTACT

bacha.kaoutar@aphp.fr

(0)676089262 ext. +33

Facility Contacts

Bacha Kaoutar

Role: primary

bacha.kaoutar@aphp.fr

(0)676089262 ext. +33

Other Identifiers

APHP210864

Identifier Type: -

Identifier Source: org_study_id