Evaluation of Ivermectin Mucoadhesive Nanosuspension as Nasal Spray in Management of Early Covid-19

NCT ID: NCT04716569

Last Updated: 2021-03-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

PHASE2/PHASE3

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-20

Study Completion Date

2021-03-20

Brief Summary

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Ivermectin showed a strong viricidal effect upon covid19 virus in vitro as proved by many authors according to many studies , covid virus stay in postnasal space for 4 days before starting general manifestation, so ivermectin mucoadhesive nanosuspension sprayed inside the nose and post nasal space may help in early management of covid19 and may play a great rule in prophylaxis as well

Detailed Description

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150 patient with early covid is devided into two groups first group will receive regular protocol of drugs second group will receive ivermectin nasal spray in addition to regular protocl of drugs

Conditions

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Covid19

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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intranasal Ivermectin group

Ivermectin group Patients who will receive intranasal ivermectin

Group Type EXPERIMENTAL

intranasal ivermectin spray

Intervention Type DRUG

usage of ivermectin as intranasal spray for treating early covid patiens

Control group

patients who will receive regular protocol drugs

Group Type OTHER

intranasal ivermectin spray

Intervention Type DRUG

usage of ivermectin as intranasal spray for treating early covid patiens

Interventions

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intranasal ivermectin spray

usage of ivermectin as intranasal spray for treating early covid patiens

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* early covid19 pateints

Exclusion Criteria

* children and pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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South Valley University

OTHER

Sponsor Role lead

Responsible Party

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Zaky Aref

ass.professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Zaky Aref

Qina, Qena Governorate, Egypt

Site Status RECRUITING

Countries

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Egypt

Facility Contacts

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Zaky Aref, MD

Role: primary

01001771210

mohammed hosny hassaan, MD

Role: backup

00201115390073

References

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Aref ZF, Bazeed SEES, Hassan MH, Hassan AS, Rashad A, Hassan RG, Abdelmaksoud AA. Clinical, Biochemical and Molecular Evaluations of Ivermectin Mucoadhesive Nanosuspension Nasal Spray in Reducing Upper Respiratory Symptoms of Mild COVID-19. Int J Nanomedicine. 2021 Jun 15;16:4063-4072. doi: 10.2147/IJN.S313093. eCollection 2021.

Reference Type DERIVED
PMID: 34163159 (View on PubMed)

Other Identifiers

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SVU MED CIT0 23 4 21 1 120

Identifier Type: -

Identifier Source: org_study_id

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