Posterior Nasal Nerve Neurectomy for Treatment of Intractable Allergic Rhinitis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-25

Study Completion Date

2026-05-31

Brief Summary

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This study aims to compare the outcomes of posterior nasal nerve neurectomy in patients with resistant Allergic rhinitis by using three different methods ( surgical resection vs radiofrequency ablation vs surface coblation ) through assesment of functional outcomes, postoperative complications, and impacts on quality of life.

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Detailed Description

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Conditions

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Intractable Allergic Rhinitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Posterior nasal neurectomy by surgical resection

Group Type ACTIVE_COMPARATOR

Posterior Nasal Nerve neurectomy

Intervention Type DEVICE

Posterior Nasal Nerve neurectomy which is done by surgical resection.

Posterior nasal neurectomy by radio- frequency ablation

Group Type ACTIVE_COMPARATOR

Posterior Nasal Nerve neurectomy

Intervention Type DEVICE

Posterior Nasal Nerve neurectomy which is done by using radiofrequency ablaion.

Surface coblation on area of the course of the Posterior nasal nerve

Group Type ACTIVE_COMPARATOR

Posterior Nasal Nerve neurectomy

Intervention Type DEVICE

Posterior Nasal Nerve neurectomy by coblation of the surface of the course of the nerve

Interventions

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Posterior Nasal Nerve neurectomy

Posterior Nasal Nerve neurectomy which is done by surgical resection.

Intervention Type DEVICE

Posterior Nasal Nerve neurectomy

Posterior Nasal Nerve neurectomy which is done by using radiofrequency ablaion.

Intervention Type DEVICE

Posterior Nasal Nerve neurectomy

Posterior Nasal Nerve neurectomy by coblation of the surface of the course of the nerve

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients aged 16 to 65 years, fit for surgery, diagnosed as moderate to severe persistent Allergic Rhinitis, as per the ARIA guidelines having 3 or more of the typical symptoms of Allergic Rhinitis including nasal discharge, repeated attacks of sneezing, nasal itching and nasal obstruction.

Exclusion Criteria

* • Patients with Coexisting nasal pathologies that could influence the outcomes of the surgery like: chronic granulomatous diseases of the nose, nasal tumors, chronic sinsitis with or without nasal polyps, etc.

* Patients who had used topical steroid nasal spray, oral or topical antihistamines, oral leukotriene antagonists, oral or tobical nasal decongestants in the last 2 weeks.
* Immunocompromised patients, Systemic disease affecting prognosis such as diabetes mellitus, hypertension,chronic liver failure or heart failure.
* Unwillingness for endoscopic surgery.
* Patients younger than 18 years of age.
* Patients who are unfit for general anesthesia.
* Previous history of nasal surgery

Minimum Eligible Age

16 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No