Retrospective Cohort Study on the Impact of PDL Treatment History on the Efficacy of HMME-PDT in Treating PWS Children
NCT ID: NCT06875492
Last Updated: 2025-03-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
273 participants
OBSERVATIONAL
2024-04-01
2024-09-01
Brief Summary
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The study population included patients without a history of PDL treatment and patients with a history of PDL treatment.
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Detailed Description
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Methods Data was gathered for individuals with PWS aged 1-3 years who received two or more Hemoporfin-PDT treatments. The study population was stratified into two groups: Cohort 1 (No PDL) comprised patients without a history of PDL treatment, while Cohort 2 (Prior PDL) consisted of patients with a history of PDL treatment. An analysis was conducted to investigate the relationship between treatment efficacy and variables including gender, age, location, and type of PWS.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Cohort 1 (No PDL)
Cohort 1 (No PDL) comprised patients without a history of PDL treatment
HMME-PDT
Twice HMME-PDT, and the treatment interval is 2 to 3 months.
Cohort 2 (Prior PDL)
Cohort 2 (Prior PDL) consisted of patients with a history of PDL treatment
HMME-PDT
Twice HMME-PDT, and the treatment interval is 2 to 3 months.
PDL
Prior PDL treatment history.
Interventions
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HMME-PDT
Twice HMME-PDT, and the treatment interval is 2 to 3 months.
PDL
Prior PDL treatment history.
Eligibility Criteria
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Inclusion Criteria
* Patients who, after evaluation by a clinician, are deemed eligible for HMME-PDT treatment and whose guardians have signed an informed consent form.
* Patients who have undergone two or more HMME-PDT treatments.
④ Patients with complete basic information and treatment-related information.
Exclusion Criteria
* Exclusion of patients with a history of treatments for PWS other than PDL treatment.
* Patients with other vascular malformations. ④ Exclusion of patients who have received any other PWS treatment within 2 months prior to HMME-PDT treatment.
1 Year
3 Years
ALL
No
Sponsors
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Second Affiliated Hospital of Xi'an Jiaotong University
OTHER
Responsible Party
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Weihui Zeng
Professor
Principal Investigators
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Weihui Zeng
Role: STUDY_CHAIR
Second Affiliated Hospital of Xi'an Jiaotong University
Locations
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The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, Shaanxi, China
Countries
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Other Identifiers
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2024218
Identifier Type: -
Identifier Source: org_study_id
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