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Carpal Tunnel Syndrome Treatment: Surgery Vs. Injections

NCT ID: NCT06852131

Last Updated: 2025-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-01-01

Brief Summary

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This prospective randomized controlled study included 68 patients (aged 18-70) with mild to moderate carpal tunnel syndrome (CTS), randomized into three groups: surgical treatment (25 patients, 25 wrists), corticosteroid (CS) treatment (20 patients, 32 wrists), and platelet-rich plasma (PRP) treatment (23 patients, 35 wrists). Diagnosis was confirmed through clinical evaluation and electrodiagnostic (EDX) testing, with assessments including the Visual Analog Scale (VAS), Boston Carpal Tunnel Questionnaire (BCTQ), ultrasonographic median nerve cross-sectional area (CSA) and flattening ratio (FR), and sensory/motor conduction parameters. Treatments were ultrasound-guided CS (1 mL triamcinolone, 40 mg/mL) or PRP (1 mL extracted from centrifuged venous blood) injections, while surgical treatment involved standard open carpal tunnel release using the WALANT (Wide Awake Local Anesthesia No Tourniquet) technique. Follow-ups were conducted at 1, 3, and 6 months, and the study was ethically approved with informed patient consent.

Detailed Description

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Conditions

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Carpal Tunnel Syndrome (CTS)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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surgery group

Group Type ACTIVE_COMPARATOR

open carpal tunnel surgery

Intervention Type PROCEDURE

open carpal tunnel surgery

steroid injection group

Group Type ACTIVE_COMPARATOR

Steroid Injection

Intervention Type PROCEDURE

triamsinolon injection

prp injection group

Group Type ACTIVE_COMPARATOR

PRP injection

Intervention Type PROCEDURE

PRP injection

Interventions

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open carpal tunnel surgery

open carpal tunnel surgery

Intervention Type PROCEDURE

Steroid Injection

triamsinolon injection

Intervention Type PROCEDURE

PRP injection

PRP injection

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

minimum of 3 months duration of symptoms and mild to moderate CTS

Exclusion Criteria

* 1\) Patients with severe CTS diagnosed with EMG or the presence of thenar atrophy, 2) Polyneuropathy, 3) Previous injection therapy for CTS, 4) Previous CTS surgery, 5) Pregnancy or lactation.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ankara University

OTHER

Sponsor Role lead

Responsible Party

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Yusuf Kıratlıoğlu

ankara university

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ankara University

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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İ02-82-22

Identifier Type: -

Identifier Source: org_study_id