Evaluation of Effects on Skin Quality of a Centella Asiatica Extracellular Vesicle-based Skin Care Formulation.

NCT ID: NCT06850935

Last Updated: 2025-03-03

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-09-04
• Study Completion Date: 2024-10-16

Brief Summary

The study evaluates the effects of a skin care formulation containing Centella asiatica extracellular vesicles as the main active ingredient on facial appearance and skin quality in healthy participants.

Detailed Description

Twenty healthy participants will be enrolled and will first undergo a 24-hour skin patch test on the forearm to assess potential irritation or allergic reactions to the test product. After screening, participants were asked to use the test product twice daily (morning and evening) after cleansing their face without using exfoliating products for 28 consecutive days. Each application involved 2 drops, evenly applied to the face using fingertips for absorption. Product usage was self-recorded, and the products were stored at room temperature.

The skin quality tests were conducted at the investigation site Hungkuang University onsite by the principal investigator. Each participant was to allocate 1 hour per test (including cleansing and waiting time). Skin quality tests were performed as a baseline test on day 0 (before using the test product), and subsequent tests at 7, 14, 21, and 28 days after test product use.

Measured parameters during assessment will include skin hydration, melanin content, skin elasticity, wrinkle percentage, redness area percentage, and pore percentage.

Conditions

Skin Quality; Skin Wrinkles; Melanin Hyperpigmentation; Skin Hydration; Skin Elasticity; Skin Redness

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Centella asiatica extracellular vesicle formulation

Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient.

Group Type: EXPERIMENTAL

Centella asiatica extracellular vesicle formulation

Intervention Type: OTHER

Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient. Applied twice daily at two drops per use to the face after face cleansing for 28 consecutive days.

Interventions

Centella asiatica extracellular vesicle formulation

Water-based formulation containing purified Centella asiatica extracellular vesicle as main active ingredient. Applied twice daily at two drops per use to the face after face cleansing for 28 consecutive days.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Healthy adults of any gender from the age of 18 to 60 years (inclusive).
• Absence of chronic diseases, major illnesses, or allergies.

Exclusion Criteria

• Currently using any medications or other skincare products

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hungkuang University

OTHER

Sponsor Role: lead

Responsible Party

Tsong-Min Chang

Vice President

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Hungkuang University

Taichung, , Taiwan

Countries

Taiwan

Other Identifiers

24-064-A

Identifier Type: -

Identifier Source: org_study_id