The Prophylactic Effect of Garlic Tablets to Prevent Nosocomial Infections in Intensive Care Unit Patients.

NCT ID: NCT06833125

Last Updated: 2025-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Clinical Phase

PHASE3

Total Enrollment

62 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-01

Study Completion Date

2026-04-01

Brief Summary

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The goal of this clinical trial is to learn if garlic tablets works to prevent nosocomial infections in hospitalized patients in ICU. The main questions it aims to answer are:

Does garlic tablets administration lower the occurence of nosocomial infections in hospitalized patients in ICU?

Detailed Description

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Conditions

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Nosocomial Infection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

It is a randomized non blinded controlled trial. Eligible patients will be randomly divided into two groups: An intervention group which will receive garlic tablets (Tomex plus 300 mg) two tablets twice daily for 6 days just after ICU admission and a control group which will not receive the garlic tablets.
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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The intervention group

The patients in the intervention group which will receive garlic tablets (Tomex plus 300 mg) two tablets twice daily for 6 days just after ICU admission

Group Type EXPERIMENTAL

Garlic powder standardized to allicin

Intervention Type DRUG

The intervention is the administration of garlic tablets (Tomex plus 300 mg) two tablets twice daily (which contains 5.4 mg allicin the active ingredient with anibacterial effect) for 6 days just after ICU admission

The control group

The patients in the control group which will not receive the garlic tablets.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Garlic powder standardized to allicin

The intervention is the administration of garlic tablets (Tomex plus 300 mg) two tablets twice daily (which contains 5.4 mg allicin the active ingredient with anibacterial effect) for 6 days just after ICU admission

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* All patients aged from 18 to 65 years old admitted to intensive care units without any type of infection.

Exclusion Criteria

1. Patients with signs /symptoms of infection.
2. Patients with human immunodeficiency virus, malignancy and patients with a history of recent immunosuppressants or corticosteroids administration.
3. Patients with bleeding disorders or abnormal coagulation profile
4. Patients who will planned for surgery within 2 weeks.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alexandria University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Alexandria Main University Hospital

Alexandria, Alexandria Governorate, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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0108752

Identifier Type: -

Identifier Source: org_study_id

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