Allicin Bioavailability From Garlic Supplements and Garlic Foods
NCT ID: NCT00874666
Last Updated: 2009-11-20
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
UNKNOWN
EARLY_PHASE1
12 participants
INTERVENTIONAL
2009-04-30
2011-04-30
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
* supplement manufacturers and clinical investigators know how supplements need to be made and consumed to obtain high bioavailability
* consumers can know how garlic can be prepared to obtain any established health benefits of garlic.
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
To resolve these issues, this study will determine the actual bioavailability of allicin from several types of garlic supplements and garlic foods under various conditions. Bioavailability will be determined by measuring the area under the 32-hour curve for breath concentrations of allyl methyl sulfide, the main metabolite allicin.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Keywords
Explore important study keywords that can help with search, categorization, and topic discovery.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NON_RANDOMIZED
CROSSOVER
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
1
Positive control with 100% allicin bioavailability
crushed garlic clove
1 gram crushed garlic in gelatin capsules, one dose once every 2-16 weeks
2
garlic powder tablet
garlic powder tablet
tablets, dose to contain 1 gram of garlic powder, consume one dose once every two weeks for up to 52 weeks
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
crushed garlic clove
1 gram crushed garlic in gelatin capsules, one dose once every 2-16 weeks
garlic powder tablet
tablets, dose to contain 1 gram of garlic powder, consume one dose once every two weeks for up to 52 weeks
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* BMI (body mass index): 19-32 kg/m2
* not planning to move out of the area in the next year
* willing to abstain from consuming garlic and onion and foods that contain them for two days prior to and during each test (diet restrictions)
* able to deliver bags of breath to the research facility five times in two days
* willing to eat whole wheat tuna sandwiches
Exclusion Criteria
* known allergy to garlic or wheat
* tobacco user
* excessive alcohol intake (³2 drinks/day, self-reported)
* unable to speak English well
18 Years
72 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Center for Complementary and Integrative Health (NCCIH)
NIH
Silliker, Inc.
INDUSTRY
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Silliker, Inc.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Larry D Lawson, Ph. D.
Role: PRINCIPAL_INVESTIGATOR
Silliker, Inc.
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
Silliker, Inc.
Orem, Utah, United States
Countries
Review the countries where the study has at least one active or historical site.
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.