tDCS for Laryngeal Dystonia

NCT ID: NCT06830174

Last Updated: 2026-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-04-14

Study Completion Date

2026-12-31

Brief Summary

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This project will apply transcranial direct current stimulation (tDCS) to multiple brain areas to evaluate the effects as a potential treatment for laryngeal dystonia (formerly spasmodic dysphonia).

Detailed Description

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Baseline neuroimaging data will be acquired from all participants via MRI, EEG. Each participant will be seen for multiple testing sessions over a five day period. LD participants will undergo the neuromodulation (HD-tDCS Stimulation) for twenty minutes while engaged in watching videos/movies or performing a word production task.

Conditions

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Laryngeal Dystonia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Subjects and staff will be blind during the study and that subjects will be told of their assignment at the follow-up visit.

Study Groups

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Laryngeal Dystonia (LD) tDCS

Adductor, Abductor and Mixed type LD with clinical evaluation of LD or with proof of LD diagnosis

Group Type EXPERIMENTAL

Starstim system

Intervention Type DEVICE

Transcranial direct current stimulation (tDCS)

Interventions

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Starstim system

Transcranial direct current stimulation (tDCS)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Participants must be clinically evaluated for the diagnosis of LD or have the proof of LD diagnosis. (Not applicable for control participants)
* No other known or history of speech, voice disorder other than LD.
* Provision of signed and dated informed consent form.
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Must not be pregnant.

Exclusion Criteria

* All individuals who do not meet the above mentioned criteria are excluded from the study.
* Subjects with a history of epilepsy or depression or is claustrophobic.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Spasmodic Dysphonia Association

OTHER

Sponsor Role collaborator

Yale University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nabin Koirala, PhD

Role: PRINCIPAL_INVESTIGATOR

Yale University

Locations

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Yale University

New Haven, Connecticut, United States

Site Status RECRUITING

Countries

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United States

Central Contacts

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Nabin Koirala, PhD

Role: CONTACT

203 7852527

Facility Contacts

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Nabin Koirala, PhD

Role: primary

203-785-2527

Other Identifiers

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2000032414

Identifier Type: -

Identifier Source: org_study_id

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