Outcomes of Complete Versus Partial Preservation of the Sub-valvular Apparatus in Cases of Mitral Valve Replacement
NCT ID: NCT06811662
Last Updated: 2025-02-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
80 participants
INTERVENTIONAL
2025-02-01
2027-12-31
Brief Summary
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Detailed Description
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patients with LV dysfunction after MVR have a significantly lower 8-year survival rate compares with patients who did not have LV dysfunction Papillary muscles play an important role in the left ventricular contraction by drawing the mitral ring toward the apex, thereby causing shortening of the long axis and spherity of the chamber contribute for better ejection of blood.
preservation of papillary muscles and chordae tendineae in MVR reduces postoperative mortality, low cardiac output syndrome and improves haemodynamic function.
Partial preservation of the mitral apparatus through preservation of the posterior leaflet (MVR-P) has been proven to significantly reduce perioperative mortality.
The importance of complete preservation of the mitral apparatus remains controversial, but it is hypothesized that complete preservation with preservation of both the anterior and posterior leaflets may contribute to superior postoperative hemodynamic function as compared to partial preservation.
Due to the increased technical complexity of preserving both leaflets, concerns about longer bypass and cross-clamp times, the need to undersize prostheses, and the possibility of left ventricular outflow tract (LVOT) obstruction, the majority of cardiac surgeons currently prefer to preserve the posterior leaflet alone.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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complete (preservation of both anterior and posterior leaflets) preservation of subvalvular apparatu
complete (preservation of both anterior and posterior leaflets) preservation of subvalvular apparatus
mitral valve replacement
complete versus partial preservation of subvavular apparatus during mitral valve replacement
partial (preservation of posterior leaflet only) preservation of subvalvular apparatus
partial (preservation of posterior leaflet only) preservation of subvalvular apparatus
mitral valve replacement
complete versus partial preservation of subvavular apparatus during mitral valve replacement
Interventions
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mitral valve replacement
complete versus partial preservation of subvavular apparatus during mitral valve replacement
Eligibility Criteria
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Inclusion Criteria
* Rheumatic mitral disease indicated for mitral valve replacement
* Concomitant other valve disease
Exclusion Criteria
* Patients with ischemic mitral disease.
* emergency operation.
* patients with significant comorbidities (severe pulmonary disease or end stage renal disease).
18 Years
60 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Amr Mohamed Mamdouh Hussein
dr
Locations
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Assiut University Heart Hosiptal
Asyut, , Egypt
Countries
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Central Contacts
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Facility Contacts
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assiut university assiut university
Role: primary
Other Identifiers
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preservation of MV leaflts
Identifier Type: -
Identifier Source: org_study_id
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