Risk Stratification and Heterogeneity for Organ Damage in Acute Diquat Poisoning

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

193 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-01

Study Completion Date

2026-12-31

Brief Summary

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This study aims to characterize the relationship between plasma diquat concentrations and organ damage risk.

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Detailed Description

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Conditions

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Toxic Encephalopathy Diquat Poisoning

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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extracorporeal treatment

Extracorporeal treatments included hemoperfusion (HP) and continuous veno-venous hemodiafiltration (CVVHDF).

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

1. history of oral exposure to diquat solution reported by patient or proxy;
2. a specimen for the diquat plasma concentration collected immediately upon admission;
3. documentation that patients or, in case of unconsciousness of the patient, legal proxies were aware of and agreed to treatment plans.

Exclusion Criteria

1. they had ingested other toxins in addition to diquat (qualitative toxicological screening tests);
2. diquat was not detected in specimens, or plasma concentration data were unavailable;
3. patients with an exposure time (time from exposure to emergency department presentation) longer than 48 hours;
4. data on organ damage were not unavailable;
5. combined with other central nervous system injuries other than toxic encephalopathy.

Eligible Sex

ALL

Accepts Healthy Volunteers

No