FlexHD® Pliable Investigation in Implant-Based Breast Reconstruction

NCT ID: NCT06797258

Last Updated: 2025-04-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

259 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-03-26

Study Completion Date

2027-08-31

Brief Summary

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Prospective, multi-center, single-arm clinical study in females undergoing immediate implant-based breast reconstruction using a pre-pectoral technique

Detailed Description

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Conditions

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Implant Based Breast Reconstruction

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Treatment Arm

FlexHD® Pliable

Group Type EXPERIMENTAL

FlexHD® Pliable

Intervention Type DEVICE

Acellular Dermal Matrix

No intervention

Intervention Type OTHER

Historical Control Arm

Interventions

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FlexHD® Pliable

Acellular Dermal Matrix

Intervention Type DEVICE

No intervention

Historical Control Arm

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Females at least 22 years of age
* Scheduled to undergo unilateral or bilateral mastectomy with immediate implant-based, prepectoral breast reconstruction
* Willing to provide Informed Consent
* Able to return for all required study visits
* Must read and understand English language

Exclusion Criteria

* Is of childbearing potential and has a positive pregnancy test within 7 days of study procedure
* Has a residual gross tumor at the intended reconstruction site
* Has undergone previous breast surgery, such as lumpectomy or breast augmentation, at the site of implantation with the exception of a biopsy
* Has undergone previous radiation therapy to the reconstruction site or chest wall, or is scheduled to undergo post-operative radiation therapy at the reconstruction site
* Completed chemotherapy within 3 weeks prior to surgery
* Has been diagnosed with a comorbid condition determined by the investigator to place the subject at an increased risk of complications
* Has a Body Mass Index (BMI) \>35
* Has used nicotine products within 1 month of screening
* Must not have taken oral corticosteroids for a minimum of 1 month prior to the procedure or have a history of long-term use of systemic oral corticosteroids or anticipate the use during course of the study
Minimum Eligible Age

22 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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MCRA (an IQVIA business)

UNKNOWN

Sponsor Role collaborator

Bruder Consulting International, LLC

UNKNOWN

Sponsor Role collaborator

Musculoskeletal Transplant Foundation

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Jonathan Heistein, MD Plastic & Reconstructive Surgery

Fort Worth, Texas, United States

Site Status RECRUITING

Countries

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United States

Facility Contacts

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Office

Role: primary

(817) 820-0000

Other Identifiers

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MTF 2024-10-IDE

Identifier Type: -

Identifier Source: org_study_id

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