Reliability of Multiple-Repetition-Maximum Tests in Patients with Cardiovascular Disease or Risk Factors

NCT ID: NCT06796582

Last Updated: 2025-01-29

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 50 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2025-06-30

Brief Summary

Exercise training is a cornerstone in the prevention and rehabilitation of cardiovascular disease. While research has primarily focused on endurance training, resistance training becomes more and more important. The gold standard to prescribe resistance training intensity or monitor longitudinal changes is the 1-Repetition-Maximum (1-RM) test. However, particularly for unexperienced individuals, this test may not be recommendable due to the high load and an increased risk of injuries. Alternatively, there are several published formulas to estimate the 1-RM based on a multiple-repetition-maximum (or repetition-to-failure) test. However, these formulas have been primarily tested in healthy individuals. Moreover, the reliability of the 1-RM estimation based on two tests with different submaximal weight is unknown. Therefore, the present study evaluates the agreement of the 1-RM estimation (based on different formulas) between two Multiple-RM tests with different weight in 50 patients with cardiovascular disease (heart failure, coronary heart disease, atrial fibrillation) or cardiovascular risk factors (type 2 diabetes, arterial hypertension).

Conditions

Heart Failure; Coronary Heart Disease (CHD); Atrial Fibrillation (AF); Diabetes Mellitus; Arterial Hypertension

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Eligibility Criteria

Inclusion Criteria

• Age ≥ 50 years
• At least one of the following cardiovascular diseases / risk factors:
• Heart failure
• Coronary heart disease
• Atrial fibrillation
• Arterial hypertension
• Type 2 diabetes mellitus
• Clinically stable for ≥ 4 weeks
• Medical clearance to perform resistance training / strength testing
• Signed written informed consent

Exclusion Criteria

• Pregnancy
• Acute infection
• Chronic joint inflammation
• Knee, hip, ankle, wrist, elbow or shoulder pain
• Known osteoporosis (T-value ≤ -2.5)
• Uncontrolled hypertension (≥160 mmHG systolic / ≥100 mmHG diastolic)
• Known cerebral or thoracic aneurysm

• Minimum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Technical University of Munich

OTHER

Sponsor Role: lead

Responsible Party

Stephan Mueller

Exercise Physiologist (Postdoctoral Researcher)

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Stephan Mueller, Dr rer nat

Role: PRINCIPAL_INVESTIGATOR

Technical University of Munich, Department for Preventive Sports Medicine and Sports Cardiology

Central Contacts

Stephan Mueller, Dr rer nat

Role: CONTACT

stephan.mueller@mri.tum.de

+49 (0)89 289 24494

Other Identifiers

2025-27-S-CB

Identifier Type: -

Identifier Source: org_study_id