Walking Training Improves Thyroid and Cardiometabolic Markers in Postmenopausal Obesity

NCT ID: NCT06793345

Last Updated: 2025-01-27

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 36 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-09-23
• Study Completion Date: 2024-12-22

Brief Summary

The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:

Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.

Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).

Participants in control group will : not perform any physical training and maintain their usual daily activities.

Detailed Description

This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.

Conditions

Thyroid Hormones; Cardiometabolic Risk Factors

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: NONE

Study Groups

MIWT group

The MIWT group received moderate intensity intermittent walking training four times per week for 10 weeks.

Group Type: EXPERIMENTAL

Moderate intensity intermittent walking training

Intervention Type: OTHER

The intensity of the training is 60 to 80% of 6MWTdistance.

Control group

The control group received no intervention for 10 weeks.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Moderate intensity intermittent walking training

The intensity of the training is 60 to 80% of 6MWTdistance.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Body mass index≥ 30 kg.m-2.
• Age between 50 and 60.
• Amenorrhea for >12 months.
• Stable eating habits.

Exclusion Criteria

• Chronic diseases.
• Medical contraindications to physical activity.
• Hormone replacement therapy.

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Wissal Abassi

OTHER

Sponsor Role: lead

Responsible Party

Wissal Abassi

Principal Investigator

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

High Institute of Sports and Physical Education of Kef

Boulifa, Kef Governorate, Tunisia

Countries

Tunisia

Other Identifiers

Training and thyroid function

Identifier Type: -

Identifier Source: org_study_id