Thyroid Hormones Effect on Brown Adipose Tissue

NCT ID: NCT01376648

Last Updated: 2011-06-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-12-31

Study Completion Date

2012-05-31

Brief Summary

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Brown adipose tissue (BAT) is important in energy expenditure through thermogenesis although the regulatory factors are not well known in humans. There is evidence suggesting that the thyroid hormones affect BAT functions in lower mammals, but the effects of the thyroid hormones on BAT activity in humans are still unclear. The objective of this study was to investigate the effects of thyroid hormones on glucose metabolism of BAT and other organs in humans.

Detailed Description

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Twenty consecutive patients with Graves'-caused hyperthyroidism who are newly diagnosed and untreated will be studied at the Endocrine Department of Huashan Hospital, Fudan University. All subjects are screened and examined by two senior investigators. Putative BAT activity is determined by the integrated 18F-fluorodeoxyglucose (18F-FDG) PET-CT. After the first PET scan, hyperthyroid patients will be treated with Methimazole following clinical guidelines. None of them uses beta adrenergic blockade. The initial dose of methimazole employed is 10mg thrice a day. During follow-up, the thyroid hormone levels (free triiodothyronine and free thyroxine) will be measured every twenty days. The PET-CT scans and assessments will be repeated when the symptoms have disappeared and the thyroid hormone levels return to normal range. Then the dose of methimazole will be adjusted accordingly.

Conditions

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Hyperthyroidism

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Newly diagnosed and untreated hyperthyroid patients
* Informed consent was obtained

Exclusion Criteria

* History of other endocrine diseases
* Useing beta adrenergic blockade
* Pregnant women
* Pacemaker implantation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Huashan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Division of Endocrinology and Metabolism

Principal Investigators

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Yiming Li, Dr.

Role: STUDY_CHAIR

Huashan Hospital

Locations

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Huashan Hospital

Shanghai, , China

Site Status RECRUITING

Countries

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China

Central Contacts

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Yiming Li, Dr.

Role: CONTACT

862152888055

Facility Contacts

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Zhaoyun Zhang, Dr.

Role: primary

Other Identifiers

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KY2009-257

Identifier Type: -

Identifier Source: org_study_id

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