The Effect of Body Mass Index and Total Cholesterol Levels on Histopathological Grading in Breast Cancer Patients

NCT ID: NCT06786598

Last Updated: 2025-01-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

85 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-01-01

Study Completion Date

2023-10-01

Brief Summary

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Breast cancer is a widespread cancer that affects high percentiles of women worldwide.The development and aggressiveness of breast cancer cells can be evaluated depending on the histopathological grading which reflects the degree of differentiation. Several factors related to lifestyle can impact the development of breast cancer. Obesity is an important factor that received the attention in recent years. The using of body mass index(BMI) is still the common method for identifying obesity which is defined when having 30kg/m² or more. Previous epidemiological and clinical studies found that obesity was correlated with advanced breast cancer especially in postmenopausal patients . Also, the changes in cholesterol levels can influence breast cancer risk in the context of obesity. The findings of other studies is still controversial; many studies revealed that elevated total cholesterol levels could increase breast cancer risk while others found to have no effect. Due to the possibility of previous factors' effect on breast cancer progression, we purposed in this study to assess the association of BMI and total cholesterol with histopathological grading according to menopausal status among a group of breast cancer patients in Syria

Detailed Description

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Conditions

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Breast Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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cholesterol titration

Group Type EXPERIMENTAL

Cholesterol

Intervention Type DIAGNOSTIC_TEST

Qimica/kit

Interventions

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Cholesterol

Qimica/kit

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

all participants after ensurement that all their clinical and demoghraphical data are completed

Exclusion Criteria

metabolic syndromes, as well as patients with statin therapy and hormonal replacement treatment.
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Tishreen University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Tishreen university

Latakia, , Syria

Site Status

Countries

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Syria

References

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Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, Sotgia F, Lisanti MP, Frank PG. Role of cholesterol in the development and progression of breast cancer. Am J Pathol. 2011 Jan;178(1):402-12. doi: 10.1016/j.ajpath.2010.11.005. Epub 2010 Dec 23.

Reference Type BACKGROUND
PMID: 21224077 (View on PubMed)

Other Identifiers

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Institutional review board

Identifier Type: OTHER

Identifier Source: secondary_id

Breast cancer grading

Identifier Type: -

Identifier Source: org_study_id

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