Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
300 participants
OBSERVATIONAL
2022-12-15
2026-05-01
Brief Summary
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Determining whether deliberate weight loss is associated with a reduced risk of breast cancer is difficult in part because sustained weight loss is difficult to achieve and few studies have sufficient statistical power to address this question. Bariatric surgery is one of the few weight loss interventions in which significant weight loss is maintained. A limited number of previous studies have suggested a reduced risk of cancer following bariatric surgery. Recently, it showed that bariatric surgery is associated with a lower risk of several types of cancer, including an approximately 40 % reduction in the risk of postmenopausal breast cancer. However, whether bariatric surgery affects breast cancer risk in premenopausal women and whether this association is altered by estrogen receptor (ER) status has not been addressed.
The aim of this study is to examine the relationship between weight loss after laparoscopic sleeve gastrectomy (LSG) and breast cancer.
Detailed Description
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Mamagrophy is recommended for all women over the age of 40 as part of the routine cancer screening program in our country. For this reason, it is assumed that female patients over the age of 40 who have undergone LSG operation have undergone mammography as of 2022. For this reason, the data of these patients will be examined by scanning from the hospital system. Patients who have undergone mammography examination at least 3 years after the LSG operation will be included in the study. The mammograms of the patients who underwent mammography in January 2015 and later will be evaluated. The final diagnosis of breast cancer will be made with the pathology result in patients with suspicious appearance on mamagrophy.
If there is a malignancy detected as a result of the examinations, its size and pathology will be recorded. Patients' age, gender, and total weight loss will be recorded.
In this retrospective study, we aimed to determine the incidence of breast cancer in patients who had undergone LSG surgery and also to determine whether there was a change in breast cancer compared to weight loss.
The patient inclusion criteria are as follows:
* 40 years and older (age as of 2022, not the age of operation)
* LSG was applied in our clinic due to morbid obesity.
* Patients whose mamagrofi images are available in the hospital system
The patient exclusion criteria are as follows:
* Patients who underwent abdominal surgery again after LSG
* Patients whose mamagrophy image is not in the system
* Patients with suspicious findings as a result of mammography and who did not undergo additional imaging or biopsy
* Patients out of follow-up after the operation
Conditions
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Keywords
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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significant weight loss+ breast cancer
The group that lost significant weight after laparoscopic sleeve gastrectomy and was diagnosed with breast cancer
mammography
All patients are checked for mammography every year after surgery.
regain+breast cancer
The group who lost significant weight after laparoscopic sleeve gastrectomy and regained it afterwards, or who could not lose weight and were diagnosed with breast cancer
mammography
All patients are checked for mammography every year after surgery.
Interventions
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mammography
All patients are checked for mammography every year after surgery.
Eligibility Criteria
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Inclusion Criteria
* LSG was applied in our clinic due to morbid obesity.
* Patients whose mamagrofi images are available in the hospital system
Exclusion Criteria
* Patients whose mamagrophy image is not in the system
* Patients with suspicious findings as a result of mammography and who did not undergo additional imaging or biopsy
* Patients out of follow-up after the operation
40 Years
FEMALE
No
Sponsors
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Fatih Sultan Mehmet Training and Research Hospital
OTHER
Responsible Party
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ANIL ERGIN
Uzman Doktor
Locations
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Fatih Sultan Mehmet Research and Training Hospital
Istanbul, , Turkey (Türkiye)
Countries
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Central Contacts
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Facility Contacts
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anıl ergin
Role: primary
Other Identifiers
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ANILERGİNN
Identifier Type: -
Identifier Source: org_study_id