Differences in Gastric Microbiota in Patients Who Were Infected Between CagA Positive and Negative Helicobacter Pylori
NCT ID: NCT06785922
Last Updated: 2025-01-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
NA
64 participants
INTERVENTIONAL
2025-01-12
2026-12-31
Brief Summary
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The effect of Helicobacter pylori typing (CagA status) on gastric microbiota, what is the different?
Patients indicated for EGD at Siriraj Endoscopic Center will undergo a Helicobacter pylori test (Rapid urease test) If the result is positive, a stomach biopsy for gastric microbiota testing and CagA antibody testing will be conducted. Then, the patients will be divided into two groups: CagA-positive Helicobacter pylori and CagA-negative Helicobacter pylori.
To compare the differences in gastric microbiota in terms of species and biodiversity, as well as endoscopic results, etc.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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CagA positive H.pylori
CagA positive H.pylori
Stomach biopsy for gastric microbiota
Stomach biopsy for gastric microbiota testing (16S RNA sequencing)
CagA negative H.pylori
Stomach biopsy for gastric microbiota
Stomach biopsy for gastric microbiota testing (16S RNA sequencing)
Interventions
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Stomach biopsy for gastric microbiota
Stomach biopsy for gastric microbiota testing (16S RNA sequencing)
Eligibility Criteria
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Inclusion Criteria
* Helicobacter pylori infection (Rapid urease test positive)
Exclusion Criteria
* BMI ≤ 23 kg/m2
* Receiving medications that affect the gastric microbiota include Antibiotics, probiotics, or bismuth within 4 weeks, PPI within 2 weeks, NSAIDs or Metformin within 2 weeks
* History of cholecystectomy or proximal small bowel surgery
18 Years
ALL
No
Sponsors
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Mahidol University
OTHER
Responsible Party
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Locations
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Faculty of internal medicine siriraj hospital, Mahidol university
Bangkok Noi, Bangkok, Thailand
Countries
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Other Identifiers
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Si 224/2024
Identifier Type: -
Identifier Source: org_study_id
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