Correlation Between H.Pylori Colonization and Gastritis

NCT ID: NCT06015763

Last Updated: 2023-08-29

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 2 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-10-31
• Study Completion Date: 2024-12-31

Brief Summary

To study the prevelance rate of H.pylori colonization in patients with gastritis.

To correlate the H.pylori colonization with endoscopic finding. To correlate both H.pylori colonization and endoscopic finding with clinical manifestation.

Detailed Description

Helicobacter pylori is a gram negative microaerophilic spiral bacterium that is usually found in the stomach and thereby cause infection , which is associated with varying degrees of damage of superficial and glandular epithelium.

Chronic gastritis is a histological entity that is defined by an inflammatory infiltrate of lymphoblasma cells, cocsometimes polynuclear neutrophils and by progressive glandular atrophy of the gastric mucosa,and probably the main cause of chronic inflammation in the gastric mucosa which is usually caused by H.pylori infection.

In addition to chronic gastritis almost all benign gastroduodenal diseases including peptic ulcer , mucosa associated lymphoid tissue lymphoma and malignant gastroduodenal adenocarcinoma occurs due to previous H.pylori infection that is usually started with gastric precancerous lesion, gastric atrophy , gastric intestinal metaplasia , dysplasia and then turned to gastric carcinoma.

So the evaluation of H.pylori infection status yo non-infection, past infection, current infection by endoscopy has therefore become increasingly important.

The Sydney grading system is one of the most important recognised tools yo charactize histological lesions of chronic gastritis.

The system categorise gastritis according to intensity of mononuclear inflammatory cellular infiltrate , polymorph activity , atrophy , intestinal metaplasia and H.pylori density into mild , moderate and severe categories, but up till now there is non-standard histology reporting formats are still widely used for gastritis and even specialists are often frustrated by the histological definition that make it difficult to identify candidates for clinico-endoscopic surveillance.

Therefore the eradication of this bacterium aimed to interrupt the carcinogenesis process and prevent recurrence of gastritis and peptic ulcer disease.

However despite of the significant researches conducted on H.pylori colonization in gastric mucosa and its association with endoscopic finding and severity of clinical manifestations, and its impact on the Egyptian population is still a topic of debate.

Currently, there is no study has definitively determined this relationship in the Egyptian population despite the high prevalence rate of H.pylori infection

Conditions

Gastritis H Pylori

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: DIAGNOSTIC
• Blinding Strategy: NONE

Study Groups

Relation between gastritis and H.pylori

Endoscopic

Group Type: OTHER

Endoscopy

Intervention Type: PROCEDURE

Endoscopic biopsy

Interventions

Endoscopy

Endoscopic biopsy

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

• All patients with gastritis above 18 years old with chronic H.pylori infection documented by histological examination included in the study.

Exclusion Criteria

All patients mentioned above who have previous gastrointestinal surgery and patients below 18y .

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 100 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Merna Mawgoud Zaki Bechit

OTHER

Sponsor Role: lead

Responsible Party

Merna Mawgoud Zaki Bechit

Relation between H.pylori colonization and severity of gastritis

Responsibility Role: SPONSOR_INVESTIGATOR

Central Contacts

Merna Mawgoud

Role: CONTACT

mernamawgoud@gmail.com

01282213004

Fatema Abu-Bakr

Role: CONTACT

01006564000

Other Identifiers

H.pylori and gastritis

Identifier Type: -

Identifier Source: org_study_id