Hinting Task for Huntington's Disease

NCT ID: NCT06774443

Last Updated: 2026-01-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

52 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-09-01

Study Completion Date

2026-12-31

Brief Summary

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Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, characterized by movement disorders, behavioural disorders and cognitive decline. Especially the behavioural and cognitive symptoms of the disease lead to significant disability and burden for patients as well as caregivers. One of the cognitive domains affected by HD is social cognition. Social cognition is the ability to perceive, interpret and respond correctly to social information. Aspects of social cognition are emotion recognition, perspective taking (Theory of Mind), and emapathy. Social cognition problems can be related to behavioural problems, but to be able to study this relationship, it is important to be able to reliable measure social cognition impairments. There are a few social cognition tests available, but often they are not normd and validated for use in a Dutch neurological population. There is a lack of sensitive, simple, tests for measuring Theory of Mind in patients with HD. A promising test, that already has been proven valid in a psychiatric population, is the Hinting Task. The Hinting Task measures theory of mind through indirect speech, The Hinting task is a social cognition test, where hints are implicitly given in speech, which resembles what patients and caregivers frequently report as difficult in HD. The Hinting Task has already been translated into Dutch and is already being used in clinical parctice, but its sensitivity has not been studied yet in a neurological population. The aim of this study is to assess if the Hinting Task is sensitive in patients with HD and to relate the Hinting Task to other (social) cognitive measures, demographical characteristics and disease characteristics.

Detailed Description

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Conditions

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Huntington Disease

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Patients with HD

Will undergo a neuropsychological assessment

Neuropsychological assessment

Intervention Type OTHER

Neuropsychological assessment consisting of tests measuring social cognition and memory

Interventions

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Neuropsychological assessment

Neuropsychological assessment consisting of tests measuring social cognition and memory

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Confirmed diagnosis of Huntington's disease via CAG-repeat length analysis, minimum of 40 repeats
* Between 18 and 74 years of age
* Dutch speaking

Exclusion Criteria

* Presence of serious psychiatric disorders or other neurological comorbidities
Minimum Eligible Age

18 Years

Maximum Eligible Age

74 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Medical Center Groningen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Maraike Coenen

Role: PRINCIPAL_INVESTIGATOR

University Medical Center Groningen

Locations

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University Medical Center Groningen

Groningen, Provincie Groningen, Netherlands

Site Status RECRUITING

Countries

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Netherlands

Central Contacts

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Floor Gelmers

Role: CONTACT

+31 50 361 46 64

Maraike A. Coenen

Role: CONTACT

Facility Contacts

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Floor Gelmers

Role: primary

+31 50 361 46 64

Maraike Coenen

Role: backup

Other Identifiers

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t.b.a

Identifier Type: -

Identifier Source: org_study_id

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