High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit

NCT ID: NCT06771687

Last Updated: 2026-01-21

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 38 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-01-16
• Study Completion Date: 2028-10-31

Brief Summary

The goal of this clinical trial is to learn if a specific type of exercise training (high intensity interval training) can improve exercise capacity in people with a congenital heart defect that required the creation of a new connection between the right ventricle and pulmonary artery. This includes people with a truncus arteriosus, pulmonary atresia with a ventricular septal defect or severe tetralogy of Fallot. This study focuses on people aged 12 to 45 years. The main questions it aims to answer are:

• Can a 12-week home-based high intensity interval exercise training program increase the exercise capacity?
• Can factors that predict whether or not the exercise training program can increase the exercise capacity in specific people be identified?

Researchers will compare the results from the intervention group to the control group. Participants will be assigned to one of these two groups at inclusion. The control group will also receive the intervention, after the control period.

Participants will:

• Participate in a 12-week home-based exercise training program (3x30 minutes a week, digitally supervised);
• Attend 2 or 3 study visits (which partially is standard care) (2 visits for the intervention group, 3 visits for the control group);
• Each study visit includes: echocardiography, magnetic resonance imaging (MRI) of the heart, cardiopulmonary exercise testing (CPET), blood and feces sampling, and questionnaires on quality of life and physical activity.

Conditions

Congenital Heart Disease; Truncus Arteriosus; Pulmonary Atresia; Tetralogy of Fallot

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Intervention

This arm receives the 12-week exercise intervention, with a study visit before and after the intervention.

Group Type: EXPERIMENTAL

High intensity interval training

Intervention Type: BEHAVIORAL

A 12-week high intensity interval training program, with 30 minutes of exercise three times a week. The trainings can be completed at home and will be digitally supervised.

Control

This arm starts with a 12-week control period, after which the participants will also receive the 12-week exercise intervention. Participants will have a study visit before and after the control period and after the intervention. For the primary outcome parameter, only the control period will be used to compare to the intervention. For the secondary outcome parameters (predictors for response), also the intervention period of the control group will be used.

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

High intensity interval training

A 12-week high intensity interval training program, with 30 minutes of exercise three times a week. The trainings can be completed at home and will be digitally supervised.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

1. Congenital absence of an unobstructed connection between the right ventricle and pulmonary artery, requiring surgical implantation of a right ventricle to pulmonary artery conduit, including patients with:

1. Truncus arteriosus

2. Pulmonary atresia with ventricular septum defect

3. Severe tetralogy of Fallot

4. Other forms of pulmonary atresia with biventricular correction

2. Age 12 to 45 years.

3. Current follow-up in Academic Center for Congenital Heart Disease (ACAHA; Erasmus MC Rotterdam and Radboudumc Nijmegen).

4. Signed informed consent.

Exclusion Criteria

1. Ventricular arrhythmias and/or channelopathy.

2. Implantable cardioverter defibrillator implantation due to inherited arrhythmia syndromes.

3. Left ventricular ejection fraction and/or right ventricular ejection fraction less than 30 percent.

4. Elite athletes (i.e. national team, Olympians, professional athletes, exercising equal to or more than 10 h/week, according to definition in 2020 European Society of Cardiology Guidelines for Sports Cardiology and Exercise in Patients with Cardiovascular Disease).

5. Cardiovascular lesions requiring intervention (according to international guidelines).

6. Cardiovascular intervention (surgery or catheterization) less than 6 months ago.

7. Cardiovascular medication changes less than 3 months ago.

8. Hospitalization for treatment of cardiovascular events less than 6 months ago.

9. Comorbidities or developmental delay impeding exercise training (e.g. neuromuscular disease, symptomatic myocardial ischemia, syndromic diagnoses such as trisomy 21).

10. Inability to provide informed consent.

• Minimum Eligible Age: 12 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Dutch Heart Foundation

OTHER

Sponsor Role: collaborator

Radboud University Medical Center

OTHER

Sponsor Role: collaborator

Erasmus Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Beatrijs Bartelds

Principal investigator, pediatric cardiologist, associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Beatrijs Bartelds, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Erasmus Medical Center

Locations

Radboudumc

Nijmegen, Gelderland, Netherlands

Site Status: NOT_YET_RECRUITING

ErasmusMC

Rotterdam, South Holland, Netherlands

Site Status: RECRUITING

Countries

Netherlands

Central Contacts

Anouk S Moerdijk, MD

Role: CONTACT

a.moerdijk@erasmusmc.nl

+31107036264

Beatrijs Bartelds, MD, PhD

Role: CONTACT

b.bartelds@erasmusmc.nl

+31107036264

Facility Contacts

Anouk S Moerdijk, MD

Role: primary

a.moerdijk@erasmusmc.nl

+31107036264

Anouk S Moerdijk, MD

Role: primary

a.moerdijk@erasmusmc.nl

+31107036264

Other Identifiers

MEC-2023-0777

Identifier Type: -

Identifier Source: org_study_id