Periodization Resistance Training on Quality of Life in Females With Hypothyroidism
NCT ID: NCT06757712
Last Updated: 2025-09-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
75 participants
INTERVENTIONAL
2025-01-01
2025-10-15
Brief Summary
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Detailed Description
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The prevalence of hypothyroidism depends on many factors, such as age, sex and geographical factors. It's also a diet related disorder and it's usually seen when the daily intake of iodine falls below 25μg.
Hypothyroidism tends to affect women more often than men and can manifest at any age, typically observed between 40 and 70 years. No specific racial predilection has been identified in studies regarding this condition. regular exercise can improve quality of life in patients with subclinical hypothyroidism by increasing physical activity level/fitness and reducing the signs and symptoms of the disease. Exercise may therefore potentiate the effectiveness of levothyroxine and help hypothyroid individuals improve their quality of life.
Periodization of resistance training or planned changes in training volume and intensity are used to maximize strength and fitness gains. The most common of periodized resistance training plans is linear also termed classic or strength/power periodization and nonlinear periodization. The biggest difference between these two types of training plans is with nonlinear periodization changes in training volume and intensity are made more frequently. The most common type of nonlinear periodization is daily nonlinear periodization where substantial changes in training intensity and volume are made from one training session to the next training session.
So, this study will be conducted to compare between the effect of non linear and linear periodized resistance training on quality of life in females with hypothyroidism.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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non linear periodization exercise + medical treatment
It will consist of 25 females, who will receive non linear periodization exercise in addition to their medical treatment.
non linear periodization exercise
The non-linear periodized resistance training program follows a 12-week schedule with varying intensity levels across three training days per week. The intensity fluctuates between very light (VL), light (L), moderate (M), heavy (H), and very heavy (VH) workouts, distributed strategically throughout the week. Each training day implements different intensity levels, and an active rest day follows any workout session.
medical treatment
The medical treatment will be received for 12 weeks.
linear periodization exercise + medical treatment
It will consist of 25 females, who will receive linear periodization exercise in addition to their medical treatment.
linear periodization exercise
The linear periodization exercise program spans 12 weeks with systematically varied training parameters. During weeks 1-2, participants perform 3 sets of 10 repetitions, followed by 3 sets of 8 repetitions in weeks 3-4. The program progresses to 4 sets of 6 repetitions in weeks 5-6, then 3 sets of 6 repetitions during weeks 7-8. The final phases consist of 4 sets of 4 repetitions in weeks 9-10, concluding with 3 sets of 4 repetitions in weeks 11-12. Training loads advance through autoregulatory progression, where participants progress at their individual pace under supervision. While sets and repetitions remain fixed within each phase, load progression is determined by performance in the final set of each exercise, ensuring safe and effective advancement.
medical treatment
The medical treatment will be received for 12 weeks.
medical treatment
It will consist of 25 females, who will receive their medical treatment only.
medical treatment
The medical treatment will be received for 12 weeks.
Interventions
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non linear periodization exercise
The non-linear periodized resistance training program follows a 12-week schedule with varying intensity levels across three training days per week. The intensity fluctuates between very light (VL), light (L), moderate (M), heavy (H), and very heavy (VH) workouts, distributed strategically throughout the week. Each training day implements different intensity levels, and an active rest day follows any workout session.
linear periodization exercise
The linear periodization exercise program spans 12 weeks with systematically varied training parameters. During weeks 1-2, participants perform 3 sets of 10 repetitions, followed by 3 sets of 8 repetitions in weeks 3-4. The program progresses to 4 sets of 6 repetitions in weeks 5-6, then 3 sets of 6 repetitions during weeks 7-8. The final phases consist of 4 sets of 4 repetitions in weeks 9-10, concluding with 3 sets of 4 repetitions in weeks 11-12. Training loads advance through autoregulatory progression, where participants progress at their individual pace under supervision. While sets and repetitions remain fixed within each phase, load progression is determined by performance in the final set of each exercise, ensuring safe and effective advancement.
medical treatment
The medical treatment will be received for 12 weeks.
Eligibility Criteria
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Inclusion Criteria
* Be ranged from 35 to 45 years
* Female patients
* Body Mass Index 30-34.9 kg/m2 .
* triglyceride-glucose (TyG) index \> 4.5
Exclusion Criteria
* Patients with uncontrolled coronary or cerebrovascular disease
* Those who underwent musculoskeletal surgery within the previous year
* Recent history of lower and upper limb fracture , hip and shoulder dislocation.
* Cognitive impaired patients
* Patients with history of epilepsy
* Patients who participating in any other exercise program
35 Years
45 Years
FEMALE
No
Sponsors
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Cairo University
OTHER
Responsible Party
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Mona Mahmoud Mohamed Abd elhady
Principal Investigator
Principal Investigators
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Nesreen Gharib Mohamed Elnahas, PhD
Role: STUDY_CHAIR
Professor, Cairo university
Locations
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Suez University
Suez, , Egypt
Countries
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Central Contacts
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Salma Ibrahim Al Ghitany, PhD
Role: CONTACT
Facility Contacts
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Other Identifiers
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P.T.REC/012/005442
Identifier Type: -
Identifier Source: org_study_id
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