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The Effect Of Anaerobic Exercise On Bone Morphogenetic Protein 9

NCT ID: NCT05117437

Last Updated: 2021-11-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

81 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-12-03

Study Completion Date

2021-12-01

Brief Summary

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Bone morphogenetic protein (BMP) 9 from the BMP family has an important role in the remodeling of bone and cartilage. Due to these features, BMP9 can play an important role in especially anaerobic exercise training adaptations. However, the role of anaerobic exercise in these effects is still unclear. The aim of this study is to investigate the role of BMP9 on the effects of acute and chronic anaerobic exercise on bone metabolism markers. Postprandial venous blood samples were taken pre- and post- acute YOYO intermittent recovery test (level 1) in 40 trained male athletes aged 18-35 who did anaerobic sports (such as basketball, volleyball and handball) and 41 sedentary volunteers aged 18-35. Serum BMP9, as markers of bone formation and resorption; alkaline phosphatase (ALP), C-terminal telopeptide of type 1 collagen (CTX1), cartilage oligomeric matrix protein (COMP) and calcium levels were determined. The data to be obtained as a result of our study can give information about the relationship between the skeletal and bone health of the athletes and anaerobic exercise.

Detailed Description

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Conditions

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Healthy Exercise

Keywords

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Bone morphogenetic protein BMP9 anaerobic exercise

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Athletic group

Healthy male athletes who have been doing regular anaerobic sports (such as basketball, volleyball and handball) for at least 3 months

Physiological test

Intervention Type OTHER

This test was conducted to determine the endurance levels of the participants.

Physical test

Intervention Type OTHER

Height, weight, and BMI were determined

Biochemical tests

Intervention Type OTHER

BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.

Control group

Healthy sedentary (not doing regular sports for at least 3 months) men with age and physical characteristics similar to the athlete group

Physiological test

Intervention Type OTHER

This test was conducted to determine the endurance levels of the participants.

Physical test

Intervention Type OTHER

Height, weight, and BMI were determined

Biochemical tests

Intervention Type OTHER

BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.

Interventions

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Physiological test

This test was conducted to determine the endurance levels of the participants.

Intervention Type OTHER

Physical test

Height, weight, and BMI were determined

Intervention Type OTHER

Biochemical tests

BMP9, CTX1, COMP, oxLDL protein levels, ALP, GGT, TAS, TOS, OSI, NO, calcium, T-C, LDL-C, Triglyceride, HDL-C, glucose, CRP, AST, ALT, erythrocyte, mean erythrocyte volume (MCV), hematocrit, leukocyte, thrombocyte levels were determined from blood samples.

Intervention Type OTHER

Other Intervention Names

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YOYO intermittent recovery test (level 1)

Eligibility Criteria

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Inclusion Criteria

* being male
* having a body mass index of less than 30 being

Exclusion Criteria

* to have some disease or disability
* to regularly use cigarettes and alcohol
* to use any medication or antioxidant substance
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ege University

OTHER

Sponsor Role lead

Responsible Party

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Faruk Turgay

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Faruk Turgay

Role: STUDY_DIRECTOR

Ege University Faculty of Sport Sciences

Locations

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Ege University Faculty of Sport Sciences

Izmir, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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TDK-2020-22186

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

TDK-2020-22186

Identifier Type: -

Identifier Source: org_study_id