Efficacy of Diosmin and Hesperidin on Early Rehabilitation After Total Knee Arthroplasty
NCT ID: NCT06753448
Last Updated: 2025-07-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
190 participants
OBSERVATIONAL
2024-10-08
2025-06-10
Brief Summary
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Does diosmin and hesperidin combined drug decreases the lower extremity swelling, pain and increases the range of motion after primary total knee arthroplasty surgery compared to standard therapy group? Does diosmin and hesperidin combined drug decreases inflammation after total knee arthroplasty surgery.
Participants will take diosmin and hesperidin in addition to standard therapy for 14 days after total knee arthroplasty surgery. Lower extremity swelling, pain and range of motion of the patients will be recorded in every visit.
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Study group
Participants will take diosmin and hesperidin combination in addition to standard therapy for 14 days after total knee replacement surgery.
Diosmin and Hesperidin Combination
Participants will take diosmin and hesperidin combination for 14 days after total knee replacement surgery.
Control group
Participants will only take standard therapy for 14 days after total knee replacement surgery.
No interventions assigned to this group
Interventions
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Diosmin and Hesperidin Combination
Participants will take diosmin and hesperidin combination for 14 days after total knee replacement surgery.
Eligibility Criteria
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Inclusion Criteria
* Patients who are functionally ASA 1, ASA 2 or ASA 3.
Exclusion Criteria
* Patients with liver insufficiency
* Patients with allergy to diosmin or hesperidin
* Patients which are not capable to communicate
18 Years
80 Years
ALL
No
Sponsors
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Ankara Etlik City Hospital
OTHER_GOV
Responsible Party
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Ahmet Berkay Girgin
Principal Investigator
Locations
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Ankara Etlik City Hospital
Ankara, Yenimahalle, Turkey (Türkiye)
Countries
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References
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Wang Q, Jin Q, Cai L, Zhao C, Feng P, Jia J, Xu W, Qian Q, Ding Z, Xu J, Gu C, Zhang S, Shi H, Ma H, Deng Y, Zhang T, Song Y, Wang Q, Zhang Y, Zhou X, Pei L, Yang Y, Liang J, Jiang T, Li H, Liu H, Wu L, Kang P. Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial. J Bone Joint Surg Am. 2024 Mar 20;106(6):492-500. doi: 10.2106/JBJS.23.00854. Epub 2023 Dec 18.
Fotiadis E, Kenanidis E, Samoladas E, Chytas A, Lyrtzis C, Koimtzis M, Chalidis B. Are venotonic drugs effective for decreasing acute posttraumatic oedema following ankle sprain? A prospective randomized clinical trial. Arch Orthop Trauma Surg. 2011 Mar;131(3):389-92. doi: 10.1007/s00402-011-1266-9. Epub 2011 Jan 28.
Nicolaides AN. The Benefits of Micronized Purified Flavonoid Fraction (MPFF) Throughout the Progression of Chronic Venous Disease. Adv Ther. 2020 Feb;37(Suppl 1):1-5. doi: 10.1007/s12325-019-01218-8. Epub 2020 Jan 22.
Other Identifiers
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2024-1008
Identifier Type: -
Identifier Source: org_study_id
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