Hot AXIOS™ for Bile Duct Drainage in Malignant Stenosis

NCT ID: NCT06750146

Last Updated: 2026-01-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

NA

Total Enrollment

162 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-06-19

Study Completion Date

2027-05-31

Brief Summary

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The study is designed to highlight the effectiveness of the Hot AXIOS™ stent when used in accordance with standard medical practice on the evolution of the quality of life of patients with malignant biliary stenosis requiring drainage of the bile ducts after failure of ERCP, in the two months after stent placement.

Detailed Description

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The study will evaluate the quality of life in patients with malignant biliary obstruction after the placement of a lumen-apposing metal stent via endoscopic ultrasound, with an emphasis on the improvement of quality of life measured as a reduction in jaundice. Improvement in jaundice is a direct indicator of effective bile drainage and is expected to correlate with an enhancement in overall quality of life. Quality of life will be measured by means of subject response to the EORTC QLQ-BIL21, a component of the European Organization for Research and Treatment of Cancer (EORTC) designed specifically to assess the quality of life in patients with biliary tract cancer. The QLQ-BIL21 consists of 21 questions which aim to evaluate specific symptoms and issues relevant to patients with biliary tract cancer, such as jaundice, pain, digestive problems and the psychosocial impact of the disease.

Conditions

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Malignant Biliary Stenosis

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Hot AXIOS™ Recipients

The Hot AXIOS™ Stent is a flexible, fully covered self-expanding metal stent that is preloaded within the Electrocautery Enhanced Delivery System. Patients who meet all eligibility criteria will receive the Hot AXIOS™stent and their quality of life will be measured at baseline, two weeks after stent placement and two months after stent placement by the jaundice dimension of the EORTC QLQ-BIL21 questionnaire. A patient is considered enrolled after signing the study-specific Informed Consent Form (ICF). Patients who sign the ICF but subsequently do not meet one or more of the selection criteria will be considered screen failures and excluded from the study.

Group Type EXPERIMENTAL

Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System

Intervention Type DEVICE

The Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System is commercially available and can be used to bridge two lumens or organs to create an internal drain, so as to drain the bile ducts in case of failure of ERCP.

Interventions

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Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System

The Hot AXIOS™ Stent and Electrocautery Enhanced Delivery System is commercially available and can be used to bridge two lumens or organs to create an internal drain, so as to drain the bile ducts in case of failure of ERCP.

Intervention Type DEVICE

Other Intervention Names

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Hot AXIOS™

Eligibility Criteria

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Inclusion Criteria

1. Patients 18 years or older
2. Willing and able to comply with study procedures and provide written informed consent
3. Patients with failed ERCP for treatment of suspected malignant biliary obstruction
4. Patients for whom an indication for Hot AXIOS™ stent placement has been determined

Exclusion Criteria

1. Women who are pregnant, nursing or planning to become pregnant during the study
2. Patients with immediately resectable tumor or resectable during the two months of the study
3. Patients for whom the placement of a double pigtail prosthesis is planned by the investigator during the index procedure
4. Current participation in another investigation drug or device study that could interfere with the endpoints of this study
5. Persons under guardianship or curatorship
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jean-Baptiste Chevaux

Role: PRINCIPAL_INVESTIGATOR

Central Hospital, Nancy, France

Locations

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CHU de Besançon

Besançon, , France

Site Status

Clinique des Cedres, Ramsay Sante

Cornebarrieu, , France

Site Status

CHU Limoges

Limoges, , France

Site Status

Hopital Prive Jean Mermoz

Lyon, , France

Site Status

Clinique Jules Verne

Nantes, , France

Site Status

CHU Nice

Nice, , France

Site Status

Hopital Saint Antoine

Paris, , France

Site Status

Hopital Paris Saint-Joseph

Paris, , France

Site Status

Hopital Europeen Georges-Pompidou

Paris, , France

Site Status

CHU de Poitiers

Poitiers, , France

Site Status

CHU Reims

Reims, , France

Site Status

CHRU Hopital Pontchaillou

Rennes, , France

Site Status

Clinique Saint-Hilaire

Rouen, , France

Site Status

Santé Atlantique

Saint-Herblain, , France

Site Status

CHU de Strasbourg

Strasbourg, , France

Site Status

CHU Rangueil

Toulouse, , France

Site Status

CHRU de Nancy

Vandœuvre-lès-Nancy, , France

Site Status

Centre Hospitalier de Vichy

Vichy, , France

Site Status

Countries

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France

Other Identifiers

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E7209

Identifier Type: -

Identifier Source: org_study_id

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