The Effects of Endotracheal Suctioning on Pain and Serum Markers

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

110 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-30

Study Completion Date

2026-04-30

Brief Summary

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The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients. These patients are already on ventilators, which means they need suctioning to keep their airways clear, but this procedure may be uncomfortable and cause stress.

The main questions this study aims to answer are:

Does ETT suctioning raise pain levels as measured by the Critical-Care Pain Observation Tool (CPOT)? Does ETT suctioning increase certain chemicals in the blood (hypoxanthine, xanthine, and uric acid) that show stress and lack of oxygen in the body? Researchers will compare patients who have ETT suctioning (intervention group) with those who do not have suctioning during the study period (control group) to see if there are differences in pain and blood markers of stress.

Participants will:

Have pain measured before and after suctioning using the CPOT. Have blood samples taken from an existing line at three time points: 5 minutes before, 5 minutes after, and 30 minutes after suctioning.

Provide demographic information (like age, gender, and diagnosis) from medical records.

This research will help improve how pain is managed for ICU patients who cannot speak for themselves, potentially leading to better pain relief methods in the future.

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Detailed Description

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Conditions

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Intensive Care Unit ICU Intubation Critical Illness Mechanical Ventilation Pain Measurement Pain, Procedural Oxidative Stress Hypoxia Biomarkers / Blood Adult Uric Acid Sepsis COVID Influenza Pneumonia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

SINGLE

Investigators

The lab technician who results the labs will be blinded.

Study Groups

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Participants who undergo endotracheal tube (ETT) suctioning.

Participants will receive ETT suctioning as part of routine care.

Group Type EXPERIMENTAL

endotracheal tube suctioning

Intervention Type PROCEDURE

Endotracheal tube suctioning occurs as part of normal care for intubated patients. This procedure will serve as the painful procedure to assess CPOT and biomarkers of hypoxia and oxidative stress.

Participants who do not undergo ETT suctioning during the observation period.

Participants will not receive ETT suctioning during the observation periood.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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endotracheal tube suctioning

Endotracheal tube suctioning occurs as part of normal care for intubated patients. This procedure will serve as the painful procedure to assess CPOT and biomarkers of hypoxia and oxidative stress.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults (aged 18 years and older)
* Current diagnosis of flu, pneumonia, COVID, or sepsis
* Intubated and receiving mechanical ventilation.
* Have arterial lines placed
* Require endotracheal suctioning as part of their care