Effect of Kidney Replacement Therapy with Polymethylmethacrylate Membranes on Pruritus-related Quality of Life in Patients Receiving Maintenance Haemodialysis
NCT ID: NCT06671535
Last Updated: 2025-03-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
62 participants
INTERVENTIONAL
2025-01-27
2025-10-31
Brief Summary
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The main question it aims to answer is: Does the use of polymethylmethacrylate (PMMA) membranes reduce the intensity of pruritus in dialysis patients?
Researchers will compare PMMA membranes to standard polysulfone-based membranes to see if PMMA works to reduce moderate-to-severe pruritis and pruritis-related quality of life.
Participants will:
* receive maintenance hemodialysis with PMMA or polysulfone membranes for 2 months;
* fill in questionnaires about intensity of pruritis and its impact on daily life.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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PMMA arm
Patients in the experimental group will receive maintenance hemodialysis using polymetilmethacrylate membranes for 2 months.
Polymethylmethacrylate membrane
A polymethylmethacrylate hollow fiber membrane (PMMA membrane) has unique properties including the uniform structure and the adsorption property.
Polysulfone arm
Patients in the control group will receive maintenance hemodialysis using polysulfone membranes for 2 months.
polysulfone membranes
Dialyzers containing polysulfone membranes are widely used for modern dialysis therapies as they allow efficient removal of a broad spectrum of uremic toxins.
Interventions
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Polymethylmethacrylate membrane
A polymethylmethacrylate hollow fiber membrane (PMMA membrane) has unique properties including the uniform structure and the adsorption property.
polysulfone membranes
Dialyzers containing polysulfone membranes are widely used for modern dialysis therapies as they allow efficient removal of a broad spectrum of uremic toxins.
Eligibility Criteria
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Inclusion Criteria
* Moderate-to-severe pruritis (WI-NRS score ≥ 4);
* Adequate dialysis dose (spKt/V≥1,4 and/or eKt/V≥1,2);
* Dialysis treatment regimen: three sessions per week of at least 4 hours duration;
* Signed informed consent.
Exclusion Criteria
* Noncompliance of the patient with the protocol (in the investigator's opinion).
* Use of haemodiafiltration.
18 Years
ALL
No
Sponsors
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Saint Petersburg State University, Russia
OTHER
Responsible Party
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Ekaterina Parshina
Chief of Nephrology and Dialysis department
Locations
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Saint Petersburg State University Hospital
Saint Petersburg, , Russia
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PMMA and pruritis
Identifier Type: -
Identifier Source: org_study_id
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