Application of FAPI Visualization in the Assessment of Right Ventricular Dysfunction Due to Volume Overload

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ENROLLING_BY_INVITATION

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-08-15

Study Completion Date

2027-12-30

Brief Summary

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\"Bicuspid aortic stenosis represents the most prevalent form of cardiac valve disease, primarily resulting from degenerative alterations and rheumatic conditions that disrupt mitral valve function. This dysfunction exacerbates the hemodynamic burden on the right heart, leading to secondary pulmonary hypertension-a condition uniquely predisposed to myocardial fibrosis. The role of right ventricular (RV) fibrosis in pulmonary hypertension induced by bicuspid aortic stenosis remains an area of active investigation. Modifications in the extracellular matrix collagen network may mitigate excessive dilation of the pressure-overloaded right ventricle; however, fibrosis concurrently compromises cardiac performance. An increasing body of experimental evidence indicates that fibrosis is pivotal in both the onset and progression of right ventricular dysfunction. In cases of secondary pulmonary hypertension, the right ventricle endures a posterior load approximately five times greater than normal, rendering these circumstances an excellent model for examining pressure loading effects on RV structure. Notably, severe RV fibrosis persists even after hemodynamic normalization following mitral valve repair; thus, preoperative evaluation of RV fibrosis is essential for optimizing patient outcomes in individuals with secondary pulmonary hypertension attributable to bicuspid aortic stenosis.

In recent years, myocardial nuclear imaging has gained prominence as a tool for assessing myocardial fibrosis. Initial studies investigated FAPI myocardial nuclear imaging\'s efficacy in evaluating left ventricular fibrosis among patients with aortic stenosis; subsequent research elucidated its correlation with sudden cardiac death risk in individuals suffering from obstructive hypertrophic cardiomyopathy.

The comprehension regarding how myocardial fibrosis impacts right ventricular function within patients experiencing pulmonary hypertension due to bicuspid aortic stenosis remains limited. The association between histological RV fibrosis and adverse prognostic indicators as well as outcomes related to right heart failure warrants further exploration.\"

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Detailed Description

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Conditions

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Right Heart Insufficiency Tricuspid Regurgitation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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high-FAPI+

FAPI Nuclear Medicine Cardiac Imaging stronge Positive" in English.

Diagnose the patient's right heart function as well as right heart fibrosis

Intervention Type DIAGNOSTIC_TEST

Diagnose the patient\'s right heart function as well as right heart fibrosis

low-FAPI+

FAPI Nuclear Medicine Cardiac Imaging Weak Positive" in English.

Diagnose the patient's right heart function as well as right heart fibrosis

Intervention Type DIAGNOSTIC_TEST

Diagnose the patient\'s right heart function as well as right heart fibrosis

No FAPI+

FAPI nuclear medicine cardiac imaging negative

Diagnose the patients right heart function as well as right heart fibrosis

Intervention Type OTHER

Diagnose the patients right heart function as well as right heart fibrosis

Interventions

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Diagnose the patients right heart function as well as right heart fibrosis

Intervention Type OTHER

Diagnose the patient's right heart function as well as right heart fibrosis

Diagnose the patient\'s right heart function as well as right heart fibrosis

Intervention Type DIAGNOSTIC_TEST

Diagnose the patient's right heart function as well as right heart fibrosis

Diagnose the patient\'s right heart function as well as right heart fibrosis

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

Clinical diagnosis of Tricuspid valve insufficiency; must understand the purpose of the study and signed an informed consent form;

Exclusion Criteria

Combined coronary artery stenosis; Combined with aortic aneurysm related diseases; Patients with congenital heart disease;

Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Xiaozheng Zhou

Doctor, Department of Cardiovascular Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Vessel Disease, Beijing 100029, China

Responsibility Role PRINCIPAL_INVESTIGATOR