Citizen Action for Sustainable Dengue Control in Sub-Saharan Africa

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-07-15

Study Completion Date

2024-09-30

Brief Summary

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This project focuses on addressing arboviral outbreaks in Ivory Coast by involving local communities in the sustainable control of Aedes mosquitoes, utilizing scientific advice and environmental interventions. It will evaluate the impact of a participatory strategy on decreasing mosquito populations and the risk of virus transmission, aiming to provide insights for policy development on disease prevention.

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Detailed Description

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This project targets the growing threat of Aedes mosquito-borne diseases such as dengue in Africa, focusing on the Anono and Gbagba communities in Abidjan, Ivory Coast, by transitioning from traditional control approaches to a community-driven strategy. It focuses on educating and involving communities in the design of sustainable mosquito management measures, such as breeding site eradication and adult mosquito capturing, with scientific experts guiding the efforts. The approach will entail conducting sociocultural surveys and interactive workshops while also encouraging local participation and multi-sectoral collaboration. A randomized controlled trial (RCT) will test this effectiveness of this novel integrated community-based participatory intervention approach in reducing the transmission of Aedes mosquito and other arboviruses. This effort seeks to develop a scalable model for arboviral disease control, promote community resilience, and inform policy recommendations for better public health outcomes in resource-constrained urban settings.

Conditions

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Dengue

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Cluster randomized trial with 2x2 factorial design - 40 clusters, 10 clusters per study arm (4 arms)

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors

Statistician unaware of the arms allocation

Study Groups

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Control

Non-intervened control arm: no community-based larval source management (LSM) or BG-GAT intervention

Group Type NO_INTERVENTION

No interventions assigned to this group

Community-based larval source management

LSM intervention arm: Aedes larval source reduction carried out by trained and supervised local community members

Group Type EXPERIMENTAL

Community-based larval source management

Intervention Type BEHAVIORAL

This project will foster active engagement with community stakeholders, including healthcare workers, community leaders, and other key informants, through participatory meetings aimed at co-creating and developing larval source reduction measures tailored to community's needs. This method emphasizes a participatory framework, ensuring that interventions are both community-informed and culturally relevant.

Enhanced Aedes adults trapping (BG-GAT)

BG-GAT intervention arm: Aedes adult mass trapping by BG-GAT set up and maintained by trained and supervised local community members

Group Type EXPERIMENTAL

Enhanced Aedes adults trapping (BG-GAT)

Intervention Type DEVICE

Furthermore, the project intends to determine whether the addition of cost-effective, gravid female mosquito-targeting traps, specifically two Biogents Gravid Aedes Traps (BG-GAT) per household, can improve the overall success of these community-based intervention.

Community-based larval source management + Enhanced Aedes adults trapping (BG-GAT)

Combined LSM and BG-GAT intervention arm: simultaneous Aedes larval source reduction and Aedes adult mass trapping by BG-GAT carried out by trained and supervised local community members

Group Type EXPERIMENTAL

Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)

Intervention Type COMBINATION_PRODUCT

The community-based interventions and the BG-GAT deployment will be evaluated in combination to assess their individual and synergistic effects on vector control. This dual strategy combines local participation and practical, evidence-based solutions to address mosquito-borne illness transmission.

Interventions

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Community-based larval source management

This project will foster active engagement with community stakeholders, including healthcare workers, community leaders, and other key informants, through participatory meetings aimed at co-creating and developing larval source reduction measures tailored to community's needs. This method emphasizes a participatory framework, ensuring that interventions are both community-informed and culturally relevant.

Intervention Type BEHAVIORAL

Enhanced Aedes adults trapping (BG-GAT)

Furthermore, the project intends to determine whether the addition of cost-effective, gravid female mosquito-targeting traps, specifically two Biogents Gravid Aedes Traps (BG-GAT) per household, can improve the overall success of these community-based intervention.

Intervention Type DEVICE

Community-based larval source management with Enhanced Aedes adults trapping (BG-GAT)

The community-based interventions and the BG-GAT deployment will be evaluated in combination to assess their individual and synergistic effects on vector control. This dual strategy combines local participation and practical, evidence-based solutions to address mosquito-borne illness transmission.

Intervention Type COMBINATION_PRODUCT

Eligibility Criteria

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Inclusion Criteria

1. Geographical location: households must be located within the designated clusters in the two districts involved in the trial.
2. Participation in cluster arms: households must belong to a cluster that is assigned to one of the four arms (1. Control, 2. Community-based larval source management, 3 Enhanced Aedes adults trapping (BG-GAT), 4. Enhanced Aedes adults trapping (BG-GAT) + Community-based larval source management).
3. Willingness to participate: households agreed to allow researchers to place mosquito traps and conduct larval and adult mosquito surveys.
4. Socio-Environmental Data: households must agree and provide consent to participate to the socio-environmental questionnaire.

Exclusion Criteria

1. Outside of trial clusters: households located outside the designated clusters in the two districts were excluded.
2. Refusal to participate: households that do not consent to mosquito trap placement or surveys
3. Inaccessibility: households that are not accessible for regular visits or data collection (e.g., due to relocation or difficult terrain).

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes