White Matter Plasticity in Schizophrenia

NCT ID: NCT06641297

Last Updated: 2025-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

36 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-01-02

Study Completion Date

2026-12-31

Brief Summary

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Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Detailed Description

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Conditions

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Schizophrenia Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Active training

Training sessions involving playing the video game 'Guitar Hero'

Group Type ACTIVE_COMPARATOR

Music video game

Intervention Type BEHAVIORAL

The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'

Observation training

Group Type PLACEBO_COMPARATOR

Music video game

Intervention Type BEHAVIORAL

The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'

Interventions

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Music video game

The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
* age 15-45
* able to provide informed consent

Exclusion Criteria

* contraindications to MRI (metal implants, claustrophobia)
* medical condition that limits use of hands (ie, arthritis)
* Active or recent (within 6 months) substance use disorder other than nicotine
Minimum Eligible Age

15 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Maryland, Baltimore

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Maryland Psychiatric Research Center

Catonsville, Maryland, United States

Site Status RECRUITING

University of Maryland Baltimore - Maryland Psychiatric Research Center

Catonsville, Maryland, United States

Site Status NOT_YET_RECRUITING

Countries

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United States

Central Contacts

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Joshua J Chiappelli, MD

Role: CONTACT

4104026827

Facility Contacts

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Joshua Chiappelli, MD

Role: primary

410-402-6827

Joshua J Chiappelli, MD

Role: primary

410-402-6827

Other Identifiers

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HP-00081020

Identifier Type: -

Identifier Source: org_study_id

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