Impact of the COVID-19 Pandemic on Oncologic Outcomes in Colorectal Cancer
NCT ID: NCT06638957
Last Updated: 2024-10-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
14951 participants
OBSERVATIONAL
2018-01-01
2024-09-20
Brief Summary
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Main Question Does the COVID-19 pandemic lead to more advanced stages of colorectal cancer at diagnosis and higher complication rates during surgery? Is there a significant difference in recurrence-free survival between CRC patients treated before and during the pandemic?
This study found that more patients presented with advanced-stage CRC during the COVID-19 pandemic, with significantly higher rates of tumor-related complications (perforations, abscesses, and preoperative obstructions), as well as an increase in open surgeries and combined resections.
No significant difference in recurrence-free survival was observed between the pre-COVID-19 and COVID-19 periods, although postoperative complication rates were higher, especially among rectal cancer patients and those receiving preoperative chemoradiotherapy.
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Detailed Description
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The study timeline was determined by the phased social distancing measures implemented in the Republic of Korea in response to the COVID-19 pandemic. The study focused on patients with CRC who underwent surgical treatment from 2018 to 2020. The pre-COVID-19 period extended from 2018 to February 2020, and the COVID-19 period began in March 2020 with the identification of the first COVID-19 case in the Republic of Korea and subsequent government measures to prevent the spread of the disease.
Eight institutions across the Republic of Korea participated in the study, including Asan Medical Center, Seoul St. Mary's Hospital, Korea University Anam Hospital, Samsung Medical Center, Pusan National University Yangsan Hospital, Gangnam Severance Hospital, Kyungpook National University Chilgok Hospital, and Chonnam National University Hwasun Hospital. These institutions are tertiary medical centers, varying in location and size.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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patients with colorectal cancer who underwent surgical treatment from 2018 to 2020
The pre-COVID-19 period extended from 2018 to February 2020
No interventions assigned to this group
patients with colorectal cancer who underwent surgical treatment from 2020
the COVID-19 period began in March 2020 to December 2020
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* in 8 institution including Asan Medical Center, Seoul St. Mary's Hospital, Korea University Anam Hospital, Samsung Medical Center, Pusan National University Yangsan Hospital, Gangnam Severance Hospital, Kyungpook National University Chilgok Hospital, and Chonnam National University Hwasun Hospital
Exclusion Criteria
* Hereditary non-polyposis colon cancer (HNPCC)
* Cancer associated with inflammatory bowel disease (IBD)
* Colorectal cancer not proven on biopsy, and pathologies other than adenocarcinoma.
* Emergency operation
ALL
No
Sponsors
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Kyungpook National University Chilgok Hospital
OTHER
Gangnam Severance Hospital
OTHER
Chonnam National University Hospital
OTHER
Korea University Anam Hospital
OTHER
Pusan National University Yangsan Hospital
OTHER
Samsung Medical Center
OTHER
Seoul Saint Mary's Hospital
UNKNOWN
In Ja Park
OTHER
Responsible Party
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In Ja Park
Professor
Locations
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Asan medical center
Seoul, Songpa, South Korea
Countries
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Other Identifiers
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COVID
Identifier Type: -
Identifier Source: org_study_id
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