The Effect of Repetitive Transcranial Magnetic Stimulation for Internet Gaming Disorder
NCT ID: NCT06634498
Last Updated: 2024-10-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
35 participants
INTERVENTIONAL
2024-10-10
2025-06-30
Brief Summary
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Detailed Description
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Participants will receive both real intermittent theta-burst stimulation (iTBS) and sham stimulation targeting the left DLPFC. The study aims to assess how these interventions influence clinical and neural outcomes. Specifically, the experiment will measure changes in craving regulation capacity, and neural markers including resting-state functional connectivity and task-evoked activation patterns in key brain regions associated with addiction, such as the DLPFC and reward system.
The entire experimental protocol spans three weeks and follows a randomized crossover design. Participants will be randomly assigned to one of two intervention sequences: real iTBS followed by sham stimulation, or sham stimulation followed by real iTBS. Each rTMS session will utilize iTBS parameters, lasting approximately 10 minutes, with a minimum of one week between the two sessions to avoid potential carryover effects.
To evaluate the effects of the interventions, clinical assessments (Craving scores), cognitive measures (craving regulation ability), and neuroimaging data (fMRI at rest and during task performance) will be collected after each intervention session. This approach allows for a comprehensive assessment of both the short-term and potential cumulative effects of rTMS on cognitive and neural correlates of IGD, contributing valuable insights into the mechanisms by which rTMS may modulate addictive behaviors and associated neural circuits.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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real rTMS on the dlPFC
rTMS on the DLPFC Dorsolateral prefrontal cortex (DLPFC) target will be identified by the baseline functional magnetic resonance imaging (fMRI) study for regulation of craving using a separate sample. During the intervention, each participant will receive an iTBS mode intervention on this DLPFC region.
real rTMS on the dlPFC
During real rTM session, participants will perform the regulation of craving (ROC). In the rest phase, participants need to relax and rest. In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
sham rTMS on the dlPFC
Each participant will also receive a sham rTMS intervention as a controlled condition.
Sham (No Treatment)
During the sham rTMS session, participants will perform the regulation of craving (ROC). In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Interventions
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real rTMS on the dlPFC
During real rTM session, participants will perform the regulation of craving (ROC). In the rest phase, participants need to relax and rest. In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Sham (No Treatment)
During the sham rTMS session, participants will perform the regulation of craving (ROC). In the ROC task, participants will regulate craving elicited by gaming pictures using cognitive reappraisal. During the task, reaction times (RTs) and craving scores wil be recorded.
Eligibility Criteria
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Inclusion Criteria
* spent more than 50% of their online time gaming；
* engagement in one of four popular Internet game (Arena of Valor,Genshine, LOL, FPS) for over 20 hours per week for at least 1 year.
Exclusion Criteria
* current or history of psychiatric or neurological illness;
* current use of psychotropic medications;
* cognitive impairment as assessed by the Mini-International Neuropsychiatric Interview；
* surgery, head trauma or heart related diseases in the past year；
* a history of epilepsy or seizures or increased risk of seizures for any reason；
* metal implants or tattoos of the neck or head；
* claustrophobia.
18 Years
30 Years
ALL
Yes
Sponsors
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Zi-Liang Wang, Medical Ethics Committee of Zhenjiang Mental Health Center
UNKNOWN
Jin-tao Zhang
OTHER
Responsible Party
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Jin-tao Zhang
Professor
Principal Investigators
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Jin-Tao Zhang, Phd
Role: PRINCIPAL_INVESTIGATOR
Beijing Normal University
Locations
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Medical Ethics Committee of Zhenjiang Mental Health Center
Zhenjiang, Jiangsu, China
State Key Laboratory of Cognitive Neuroscience and Learning
Beijing, , China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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The effect of rTMS in IGD
Identifier Type: -
Identifier Source: org_study_id
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