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Repetitive Transcranial Magnetic Stimulation(rTMS) in the Treatment of Depression

NCT ID: NCT01198561

Last Updated: 2015-12-31

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2006-02-28

Study Completion Date

2016-12-31

Brief Summary

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The objective of this study is to investigate the antidepressant efficacy of rTMS, and to assess cortical metabolism before and after rTMS sessions in patients with major depression. We also aimed to investigate differences between the responders and nonresponders to rTMS and what would predict clinical response to rTMS.

Detailed Description

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The specific aims of this study is to: (1) evaluate the antidepressant efficacy of rTMS on major depression; (2) evaluate the effects of rTMS on cognitive function in depressive patients; (3) assess the effects of rTMS on cerebral glucose metabolism in depressive patients as measured by 18FDG PET; (4) investigate the differences of the regional cerebral glucose uptake changes during rTMS between responders and nonresponders to rTMS.

Conditions

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Major Depressive Disorder

Keywords

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repetitive Transcranial Magnetic Stimulation Major Depressive Disorder

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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repetitive Transcranial Magnetic Stimulation

repetitive Transcranial Magnetic Stimulation is a depressive patient group treated with rTMS

repetitive Transcranial Magnetic Stimulation

Intervention Type DEVICE

10 times repetitive TMS, high frequency

Interventions

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repetitive Transcranial Magnetic Stimulation

10 times repetitive TMS, high frequency

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Twenty patients fulfilling the diagnostic criteria of major depression according to DSM IV will be enrolled in the study.
* Antidepressant medication will be maintained throughout the study period.

Exclusion Criteria

* To exclude the effect of drug changes on post-rTMS cerebral glucose metabolism, the combinations and dosage of pre-rTMS antidepressant drugs will remain unchanged until the post-rTMS 18FDG PET is done.
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Doh Kwan Kim

M.D., Ph.D. / Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Doh K KIm, Ph.D

Role: PRINCIPAL_INVESTIGATOR

Samsung Medical Center

Locations

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Samsung Medical Center

Seoul, Kangnam-Ku, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Doh Kwan Kim, M.D., Ph.D.

Role: CONTACT

Phone: 82-2-3410-3582

Email: [email protected]

Facility Contacts

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Doh Kwan Kim, M.D., Ph.D.

Role: primary

Other Identifiers

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2005-08-072

Identifier Type: -

Identifier Source: org_study_id