Clinical Improvement Due to the Home Use of Agilik in Children With Cerebral Palsy

NCT ID: NCT06622655

Last Updated: 2025-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-10-29

Study Completion Date

2026-07-31

Brief Summary

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The goal of this clinical trial is to learn if a two month training with the Agilik powered orthosis improves the knee extension or the endurance in pediatric patients with Cerebral palsy and a crouch gait. It will also learn about the safety of Agilik. The main questions it aims to answer are:

Does the Agilik powered orthosis increase the value of the knee extension during walking? What medical problems do participants have when using the Agilik powered orthosis? Researchers will compare a group of patients using the Agilik powered exoskeleton with a group of patients treated with standard therapy.

Participants will:

Use Agilik at home or perform standard therapy for 2 months Visit the clinic at the beginning of the study, after 3 months and after 1 additional month.

Detailed Description

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Conditions

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Cerebral Palsy (CP)

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intervention Arm

Home rehabilitation

Group Type EXPERIMENTAL

Powered orthosis

Intervention Type DEVICE

Home rehabilitation (2 months, 30 minutes/day, 5 days/week) during which subjects will practice walking with the device at home.

Control Group

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Powered orthosis

Home rehabilitation (2 months, 30 minutes/day, 5 days/week) during which subjects will practice walking with the device at home.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of CP and a crouch gait
* Provision of signed and dated informed consent form.
* Stated willingness to comply with all study procedures and availability for the duration of the study, or alternatively, ability to do so based on parent report and physician observation during history and physical examination.
* Body weight between 20 and 125 Kg
* Knee flexion retraction assessed in supine position by less than 10°. Hamstring contracture as assessed by straight leg raising test does not limit ability to participate in the study.
* Subjects must not have had a tibio-tarsal arthrodesis. In addition, they must have at least 5° of passive dorsi-flexion of the ankle.
* Able to walk at least 3 m without stopping, with or without a walking aid.
* Able to understand and follow simple directions based on parent report and physician observation during historical and physical examination.
* GMFCS level I, II and III
* MAS score ≤ 2

Exclusion Criteria

* Any severe neurological, musculoskeletal and/or cardiorespiratory involvement preventing the ability to walk;
* A history of uncontrolled seizure in the past year
* Severe spasticity
* Hip and/or knee flexion contracture of more than 20°
Minimum Eligible Age

5 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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IRCCS Fondazione Stella Maris

OTHER

Sponsor Role collaborator

Fondazione Don Carlo Gnocchi Onlus

OTHER

Sponsor Role collaborator

Fondazione Mondino

OTHER

Sponsor Role collaborator

IRCCS Eugenio Medea

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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IRCCS E. MEDEA - Associazione "La Nostra Famiglia"

Bosisio Parini, Lecco, Italy

Site Status RECRUITING

IRCCS Fondazione Stella Maris

Calambrone, Pisa, Italy

Site Status NOT_YET_RECRUITING

Fondazione Don Carlo Gnocchi Onlus - IRCCS S. Maria Nascente

Milan, , Italy

Site Status RECRUITING

Fondazione Mondino

Pavia, , Italy

Site Status NOT_YET_RECRUITING

Fondazione Don Carlo Gnocchi Onlus

Roma, , Italy

Site Status RECRUITING

Fondazione Don Carlo Gnocchi Onlus - Centro S. Maria al Mare

Salerno, , Italy

Site Status RECRUITING

Countries

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Italy

Central Contacts

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Emilia Biffi, PhD

Role: CONTACT

+39031877862

Cristina Maghini, MD

Role: CONTACT

Facility Contacts

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Emilia Biffi, PhD

Role: primary

+39031877862

Cristina Maghini, MD

Role: backup

Giuseppina Sgandurra, MD, PhD

Role: primary

+39050886284

Angela Cavalagli, MD

Role: primary

+3902403081

Sabrina Signorini, MD

Role: primary

+3903823801

Laura Iuvone, MD

Role: primary

+3906330861

Irene Aprile, MD, PhD

Role: primary

+39089334425

Other Identifiers

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PNC0000007

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

GIP1122

Identifier Type: -

Identifier Source: org_study_id

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