Health-Related Quality of Life and Emotions in Patients with Thyroid Nodules

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-01

Study Completion Date

2027-12-31

Brief Summary

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The purpose of this observational research is to evaluate and compare the health-related quality of life and emotional well-being of patients with thyroid nodules before and after treatment. This is a data collection study by allowing investigators to access information generated before and after treatment.

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Detailed Description

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The incidence of thyroid nodules is rising worldwide. Papillary thyroid carcinoma (PTC), the most common type of thyroid cancer, has a favorable prognosis, with a low mortality rate and over 90% 10-year survival rate. Thyroidectomy is often applied to manage thyroid nodules as a traditional method. However, thermal ablation (TA), including microwave ablation (MWA), radiofrequency ablation (RFA), and laser ablation, has emerged as an alternative option for selected patients with thyroid function. TA methods are effective, safe, feasible, and have litter influence on thyroid function. Patients with thyroid nodules frequently exhibit higher levels of emotional stress compared to the general population. Additionally, health-related quality of life (QoL) has become an important endpoint and a strong predictor of survival time in medical and health research, underscoring the importance of treatments that not only prolong life but also preserve or enhance QoL. Considering the long survival time of patients with thyroid noduls and the similar therapeutic outcomes between surgery and MWA , it is crucial to pay more attention on patients\&#39; QoL and emotional well-being before and after treatment.

Conditions

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Thyroid Nodule

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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thyroidectomy

patients with thyroid nodules who undergo surgical resection

thyroidectomy

Intervention Type PROCEDURE

surgical resection of thyroid nodules

thermal ablation

patients with thyroid nodules who undergo thermal ablation

thermal ablation

Intervention Type PROCEDURE

thermal ablation including microwave ablation, radiofrequency ablation of thyroid nodules

Interventions

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thermal ablation

thermal ablation including microwave ablation, radiofrequency ablation of thyroid nodules

Intervention Type PROCEDURE

thyroidectomy

surgical resection of thyroid nodules

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Clinical diagnosis of benign thyroid nodules or papillary thyroid carcinoma ;
* underwent microwave ablation or thyroidectomy;
* ability to understand and cooperate with the survey

Exclusion Criteria

* serious primary diseases in the liver, kidney, hematopoietic, or endocrine systems；
* a history of mental illness, personality disorders, cognitive impairments, or organic brain disease

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes