US-guided RFA vs MWA in the Treatment of Benign Thyroid Nodules

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2025-03-01

Brief Summary

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To evaluate the clinical outcomes of RFA and MWA for benign thyroid nodules treatment

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Detailed Description

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The thyroid nodule is one of the most common lesions in clinical practice and has been increasingly detected in approximately 50% of the general population by ultrasound (US) examination in the past two decades due to the widespread use of radiological imaging.

Benign thyroid nodules (BTNs) proven cytologically by fine-needle aspiration biopsy (FNAB) account for 85 to 95% of all thyroid nodules.

Despite the fact that the majority of thyroid nodules diagnosed are benign and do not cause significant clinical symptoms, some nodules may lead to compression-related symptoms. In addition, thyrotoxic symptoms may develop due to hyperfunctioning of some nodules.

To date, surgical resection is the main treatment for thyroid nodules. However, it has serious drawbacks such as leading to excessive surgical trauma or hypothyroidism, influencing the aesthetic aspect of the neck, or increasing a post-operative recurrence rate.

RFA has shown good efficacy and safety in the management of thyroid nodule related cosmetic problems and pressure symptoms.

MWA is a newly developed local thermal ablation technique that has fast heating speed, strong coagulation ability and large ablation zone, and has become a great therapeutic method in heat ablation therapy (8) The advantages of ultrasound-guided minimally invasive ablation therapy over the traditional surgery include simpler operation and shorter treatment time. (8)

Conditions

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Thyroid Nodule (Benign)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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group 1

Patients with benign thyroid nodules undergo RFA

Radiofrequency ablation/Microwave ablation

Intervention Type PROCEDURE

thermal ablation by radiofrequency and Microwave

group 2

Patients with benign thyroid nodule undergo MWA

Radiofrequency ablation/Microwave ablation

Intervention Type PROCEDURE

thermal ablation by radiofrequency and Microwave

Interventions

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Radiofrequency ablation/Microwave ablation

thermal ablation by radiofrequency and Microwave

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Solid or mixed nodules with predominant solid component with benign pathological result from US guided fine needle aspiration (FNAC).
* Symptomatic and/or cosmetic problems.
* Clinical thyrotoxicosis and hyperthyroidism caused by autonomously functioning thyroid nodules (AFTNs)
* Refusal or ineligible for surgery.
* Anxiety about a malignant transformation.

Exclusion Criteria

* Malignant nodules on US.
* Cytological evidence for malignancy
* Patients with abnormal coagulation profile.
* previous surgery or medicine for the thyroid, and vocal cord palsy in the side contralateral to the target nodules.

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No