Benefits of Pulmonary Rehabilitation to Patients Post Liver Transplant

NCT ID: NCT06606184

Last Updated: 2024-09-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

78 participants

Study Classification

INTERVENTIONAL

Study Start Date

2022-01-01

Study Completion Date

2023-12-31

Brief Summary

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The goal of this clinical trial was to access the benefits of a 12-week home-based pulmonary rehabilitation regimen on pulmonary function recovery in post-liver transplant patients. The main questions it aims to answer are:

Does pulmonary rehabilitation facilitate pulmonary muscle strength recovery? Does the intervention improve pulmonary function and reduce dyspnea sensation?

Participants performed:

Inspiratory muscle training twice a day for 12 weeks after discharged from the hospital Upper limb resistive training Lower limb exercise

Detailed Description

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Patients undergoing liver transplantation often face significant challenges related to pulmonary rehabilitation. Although postoperative rehabilitation has been extensively studied, the specific role of pulmonary rehabilitation programs has received limited attention. This study aims to evaluate the efficacy of a home-based pulmonary rehabilitation program in improving respiratory function recovery among post-liver transplant patients. The training group participated in a 12-week pulmonary rehabilitation program post-discharge, emphasizing respiratory muscle and exercise training, while the control group received standard care, which included traditional rehabilitation.

Conditions

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Liver Transplant Surgery

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Inspiratory Muscle Training group

Participants received a 12-week inspiratory muscle training and incentive spirometry therapy after discharged from hospital

Group Type EXPERIMENTAL

Inspiratory muscle Training

Intervention Type PROCEDURE

Participants underwent a 12-week program consisting of inspiratory muscle training twice daily, incentive spirometry three times daily, and upper limb exercises along with marching in place for 30 minutes.

Routine care

Participants received incentive spirometry therapy only

Group Type SHAM_COMPARATOR

Routine Care

Intervention Type PROCEDURE

Participants received routine care, which included encouragement to use incentive spirometry three times daily.

Interventions

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Inspiratory muscle Training

Participants underwent a 12-week program consisting of inspiratory muscle training twice daily, incentive spirometry three times daily, and upper limb exercises along with marching in place for 30 minutes.

Intervention Type PROCEDURE

Routine Care

Participants received routine care, which included encouragement to use incentive spirometry three times daily.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Age 20 years or older
* Scheduled to undergo living donor liver transplantation
* Stable vital signs
* Normal cognitive function
* Able to perform activities independently using their own strength and coordination
* Willing and able to participate in 12 weeks of rehabilitation training

Exclusion Criteria

* Severe physical illness during the operation
* Acute bleeding
* Unstable vital signs
* Hepatic encephalopathy, or neurological conditions such as stroke, Parkinson\'s disease, or cognitive dysfunction
* Limited mobility (e.g., unable to stand, lift upper limbs, or bedridden)
* Inability to comply with 12 weeks of pulmonary rehabilitation post-discharge
* Unstable vital signs
* Hepatoencephalopathy, such as cardiovascular accident, Parkinson disease, cognitive dysfunction
* Those with limited mobility (unable to stand, unable to lift upper limbs, or bedridden)
* Those who are unable to cooperate with the 12 weeks of pulmonary rehabilitation exercises after discharge.
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung University of Science and Technology

OTHER

Sponsor Role collaborator

Chang Gung Memorial Hospital

OTHER

Sponsor Role collaborator

Chang Gung University

OTHER

Sponsor Role lead

Responsible Party

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Hui-Ling Lin

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jui-Fang Lin, PhD

Role: PRINCIPAL_INVESTIGATOR

Chang Gung University of Science and Technology

Locations

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Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status

Countries

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Taiwan

References

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Au KP, Chan SC, Chok KS, Sharr WW, Dai WC, Sin SL, Wong TC, Lo CM. Clinical factors affecting rejection rates in liver transplantation. Hepatobiliary Pancreat Dis Int. 2015 Aug;14(4):367-73. doi: 10.1016/s1499-3872(15)60391-5.

Reference Type BACKGROUND
PMID: 26256080 (View on PubMed)

Aamir,T., Iftikhar,S., Khan, R.R., &Khan, M.K (2019).Role of physiotherapy in improving quality Of life in liver transpant patients. The Rehabilitation Journal, 3(2),126-130.

Reference Type BACKGROUND

Other Identifiers

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202102058B0

Identifier Type: -

Identifier Source: org_study_id

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