Impact of Exercise Therapy on Functional Capacity in Patients Listed for Liver Transplantation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2018-08-01

Brief Summary

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A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)

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Detailed Description

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as above

Conditions

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Liver Cirrhosis Liver Dysfunction

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Intervention arm

12-week home prehabilitation program

Group Type EXPERIMENTAL

Home prehabilitation program

Intervention Type BEHAVIORAL

12-week exercise therapy using daily step program (accelerometer), functional resistance exercise sessions and telephone/virtual clinic appointments

Interventions

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Home prehabilitation program

12-week exercise therapy using daily step program (accelerometer), functional resistance exercise sessions and telephone/virtual clinic appointments

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Meet the United Kingdom Liver Transplant criteria for listing
* Accepted on the liver transplant waiting list for a primary transplant
* Adults ≥18years who have an indication for a liver transplant
* Diagnosed with sarcopenia at liver transplant assessment

Exclusion Criteria

* Significant cardiovascular instability including a recent Myocardial infarction, recent Cerebrovascular accident and/or a recent unstable arrhythmia
* Unstable encephalopathy - open to interpretation by the chief investigator
* Patient or next of kin non-English speaking
* Inpatients
* Refusal or lacks capacity to give informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No