Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic
NCT ID: NCT06600945
Last Updated: 2024-09-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
180 participants
OBSERVATIONAL
2023-02-01
2025-04-01
Brief Summary
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Detailed Description
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Among regional blocks, peribulbar block is safe to retrobulbar block due to lesser incidence of series complications such as brain-stem anesthesia globe perfusion and retrobulbar hemorrhage .
The effect of non-depolarizing neuromuscular blockers on peribulbar anesthesia has been described in many studies. According to these studies the use of atracurium as adjuvant to peribulbar anesthesia provides early onset of akinesia and improves the quality of anesthesia in absence of any adverse effect.
Magnesium sulphate is non-competitive N-Methyl-D- Aspartate (NMDA) antagonism and calcium channel blocker. Magnesium has endothelium derived Nitric Oxide induced vasodilation. It enhanced the activity of local anesthetic agent and improves the quality of anesthesia .
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Group c control group
Group C (Control group): Will undergo peribulbar block using 6ml of local anesthetic: 2ml of 0.5%bupivacaine and 1ml of 2% lidocaine mixed with hyaluronidase (150 U) + 2ml lidocaine 2 %+ 1ml 0.9% saline without atracurium and magnesium sulphate
Cataract surgery
With local anesthetic in peribulbar anesthesia
Group A atracurium group
Group A (Atracurium group): Will undergo peribulbar block using 6ml of local anesthetic: 2ml of 0.5% bupivacaine and 1ml of 2% lidocaine mixed with hyaluronidase (150 U) + 2ml lidocaine 2%+ 0.05 mg/kg atracurium (maximum 5 mg) in 1 ml of 0.9% saline .
Cataract surgery
With local anesthetic in peribulbar anesthesia
Group M magnesium sulphate group
Group M (Atracurium+ Magnesium sulfate): Will undergo peribulbar block using 6ml of local anesthetic: 2 ml of 0.5%bupivacaine and 1 ml of 2% lidocaine mixed with hyaluronidase (150 U) +2ml lidocaine2%+ (0.05 mg/kg atracurium (maximum 5 mg) + 50 mg magnesium sulfate) in 1 ml of 0.9% saline
Cataract surgery
With local anesthetic in peribulbar anesthesia
Interventions
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Cataract surgery
With local anesthetic in peribulbar anesthesia
Eligibility Criteria
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Inclusion Criteria
Patients aged 20-80 years. Both sexes. ASA physical status I\&II.
Exclusion Criteria
Patients are known to have a history of fits. Patients on medication known to interact with neuromuscular blocking drugs as antipyretics (aminoglycosides and tetracyclines), antiarrhythmic (quinidine).
Local sepsis. Coagulation abnormalities (INR\>1.4). High myopia with axial length more than 30 mm or less than 21. Mentally retarded patients and failure of proper communication as in deafness. Morbidly obese patients (BMI\>40). Patients with glaucoma (increased IOP\>20mmgh). Patients with history of hypersensitivity to study drugs. Very dense or very soft cataract .
20 Years
80 Years
ALL
Yes
Sponsors
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Minia University
OTHER
Dalia yousry Mohamed elsayed
OTHER
Responsible Party
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Dalia yousry Mohamed elsayed
Atracurium Versus Atracurium and Magnesium Sulphate as Adjuvants to Local Anesthetic for Peribulbar Anesthesia in Cataract Surgery
Locations
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Dalia yousry mohamed
Minya, , Egypt
Countries
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Facility Contacts
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Mohamed Moustafa Ali
Role: backup
Other Identifiers
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Peribulbar Anesthesia
Identifier Type: -
Identifier Source: org_study_id
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