Oct Angiography Changes After Local Anesthesia in Cataract Surgery
NCT ID: NCT07298746
Last Updated: 2025-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
100 participants
INTERVENTIONAL
2025-12-31
2027-03-31
Brief Summary
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Detailed Description
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Optical coherence tomography angiography (OCTA) will be performed before and after the administration of retrobulbar and peribulbar local anesthesia in the same cohort of patients, in order to evaluate the immediate effects of the anesthetic intervention on retinal microvascular parameters.the study will be conducted on patients aged 40-80 years with elective cataract surgery requiring regional block.the study will be divided into two main groups :
1. Group with peribulbar anesthesia injection.
2. Group with retrobulbar anesthesia injection.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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group A
peribulbar anesthesia injection of two anesthetic agents ( lidocaine 2 %+ hyaluronidase 150IU\\ML )
Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML)
peribular injection of both lidocaine 2 % and hyaluronidase 150IU\\ML
group A1
peribulbar anesthesia injection ( mepivacaine 2% + hyaluronidase 150IU\\ML )
Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)
peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML
group B
retrobulbar anesthesia injection ( lidocaine 2 %+ hyaluronidase 150IU\\ML )
Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)
retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\\ML
group B1
retrobulbar anesthesia injection ( mepivacaine 2% + hyaluronidase 150IU\\ML )
local Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)
retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML
Interventions
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Local Anesthesia (peribular injection of both lidocaine 2 % and hyaluronidase 150IU\ML)
peribular injection of both lidocaine 2 % and hyaluronidase 150IU\\ML
Local Anesthesia (peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)
peribulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML
Local Anesthesia (retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\ML)
retrobulbar anesthesia injection of lidocaine 2 % and hyaluronidase 150IU\\ML
local Anesthesia (retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\ML)
retrobulbar anesthesia injection of mepivacaine 2% and hyaluronidase 150IU\\ML
Eligibility Criteria
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Inclusion Criteria
2. patients with elective cataract surgery requiring regional block.
Exclusion Criteria
opacities, etc). 3. Patients with any other retinal vascular diseases (retinal vein occlusion, central serous chorioretinopathy, age-related macular degeneration, etc).
4\. Patients who have had previous intravitreal injections or Laser treatment. 5. Patients who underwent previous vitreoretinal surgeries. 6. Patients with uncontrolled glaucoma or ocular inflammations (eg: vitritis). 7.Patients with diabetes mellitus or hypertension.
40 Years
80 Years
ALL
No
Sponsors
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Sohag University
OTHER
Responsible Party
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Amira Aldesoky Ahmed
Principal Investigator
Central Contacts
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Mohamed Anber Abdellatif, professor
Role: CONTACT
Phone: 01009801966
References
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Ali H, Eissa S, Magdy H, Khashba M. Dexmedetomidine as an Additive to Local Anesthesia for Decreasing Intraocular Pressure in Glaucoma Surgery: A Randomized Trial. Anesth Pain Med. 2020 Jun 27;10(3):e100673. doi: 10.5812/aapm.100673. eCollection 2020 Jun.
Rao HL, Pradhan ZS, Suh MH, Moghimi S, Mansouri K, Weinreb RN. Optical Coherence Tomography Angiography in Glaucoma. J Glaucoma. 2020 Apr;29(4):312-321. doi: 10.1097/IJG.0000000000001463.
Kalra G, Zarranz-Ventura J, Chahal R, Bernal-Morales C, Lupidi M, Chhablani J. Optical coherence tomography (OCT) angiolytics: a review of OCT angiography quantitative biomarkers. Surv Ophthalmol. 2022 Jul-Aug;67(4):1118-1134. doi: 10.1016/j.survophthal.2021.11.002. Epub 2021 Nov 5.
Other Identifiers
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Soh-Med-25-9-22MS
Identifier Type: -
Identifier Source: org_study_id