Serum Uromodulin and DN Systematic Review and Meta Analysis

NCT ID: NCT06596863

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1774 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-05-01

Study Completion Date

2024-05-30

Brief Summary

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Several studies have investigated the association between the changes of serum uromodulin and diabetic nephropathy (DN). However, the results are still controversial. Hence, this meta-analysis aimed to evaluate the association of uromodulin with DN.

Detailed Description

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Conditions

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Diabetic Nephropathies

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Control group

Included 862 healthy subjects as control group

The association of serum uromodulin with DN

Intervention Type DIAGNOSTIC_TEST

Meta analysis of association of serum uromodulin with DKD

The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Intervention Type DIAGNOSTIC_TEST

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

DKD group

Included 912 patients with DN

The association of serum uromodulin with DN

Intervention Type DIAGNOSTIC_TEST

Meta analysis of association of serum uromodulin with DKD

The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Intervention Type DIAGNOSTIC_TEST

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Interventions

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The association of serum uromodulin with DN

Meta analysis of association of serum uromodulin with DKD

Intervention Type DIAGNOSTIC_TEST

The DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

DN patients were divided according to the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Studies were included if they met the following criteria:

1. serum level of uromodulin was determined;
2. the samples were enrolled from diabetic patients;
3. mean ± SD was reported for uromodulin between patients with and without DN;
4. the level of albumin to creatinine ratio (ACR), glomerular filtration rate (GFR), or albumin excretion rate (AER) in patients with DN was determined

Exclusion Criteria

* Studies were excluded according to the following criteria:

1. duplicate studies;
2. review articles;
3. non original research articles;
4. studies with insufficient data to extract;
5. non-human research;
6. studies that determined urine level of uromodulin.
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Ain Shams University

OTHER

Sponsor Role collaborator

Tanta University

OTHER

Sponsor Role lead

Responsible Party

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Shaimaa Ibrahim Barr

Dr of Biochemistry

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Tanta Yniversity

Tanta, Yes, Egypt

Site Status

Countries

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Egypt

Other Identifiers

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DKD serum uromodulin

Identifier Type: -

Identifier Source: org_study_id

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