A Multicenter Pediatric Deep Brain Stimulation Registry

NCT ID: NCT06585618

Last Updated: 2024-10-15

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-07-30
• Study Completion Date: 2029-07-30

Brief Summary

There is limited data on outcomes for children who have undergone deep brain stimulation (DBS) for movement disorders, and individual centers performing this surgery often lack sufficient cases to power research studies adequately. This study aims to develop a multicenter pediatric DBS registry that allows multiple sites to share clinical pediatric DBS data. The primary goals are to enable large-scale, well-powered analyses of the safety and efficacy of DBS in the pediatric population and to further explore and refine DBS as a therapeutic option for children with dystonia and other hyperkinetic movement disorders. Given the current scarcity of evidence available to clinicians, this centralized multicenter repository of clinical data is critical for addressing key research questions and improving clinical practice for pediatric DBS.

Detailed Description

The use of deep brain stimulation (DBS) has expanded to include multiple conditions in children including dystonia, epilepsy, Tourette syndrome and mood disorders. Despite its growing application, DBS remains a low-volume procedure in most pediatric centers, which limits opportunities for large-scale research studies. To overcome this challenge, an international data-sharing platform is essential for advancing knowledge about DBS in pediatric patients, particularly concerning surgical techniques and patient outcomes across various conditions.

This study aims to establish a multicenter pediatric DBS registry. With limited data on pediatric DBS outcomes and a small number of cases at individual centers, there is a need for a comprehensive registry to enable large-scale, well-powered analyses of DBS safety and effectiveness. The primary goals of this study are to:

• Establish and implement a multi-center pediatric DBS registry
• Facilitate large-scale analyses of DBS safety and effectiveness in children
• Refine DBS as a treatment option for dystonia and other hyperkinetic movement disorders in children.

Secondary objectives include:

• Identifying which patients benefit most from DBS
• Determining clinical variables that influence DBS responsiveness
• Identifying optimal implant sites for specific conditions
• Understanding the long-term effects of DBS in children
• Assessing the impact of DBS on the quality of life in pediatric patients

The study will involve both prospective and retrospective data collection from pediatric DBS patients.

Conditions

Dystonia; Epilepsy in Children; Cerebral Palsy; Tourette Syndrome; Obsessive-Compulsive Disorder; Neurologic Disorder; Movement Disorders in Children; Movement Disorders; Deep Brain Stimulation

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Female or male patients between ages of 0-18 years.
• Having received or scheduled to receive DBS for any neurological movement disorder.
• Parents or legal guardians are able to provide written consent for prospective enrollment.

• Minimum Eligible Age: 0 Years
• Maximum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Boston Children's Hospital

OTHER

Sponsor Role: lead

Responsible Party

Darius Ebrahimi-Fakhari

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Boston Children's Hospital

Boston, Massachusetts, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Darius Ebrahimi-Fakhari, MD, PhD

Role: CONTACT

movementdisorders@children.harvard.edu

617-355-0097

Kathryn Yang, MBChB, FRCPC

Role: CONTACT

movementdisorders@children.harvard.edu

Facility Contacts

Darius Ebrahimi-Fakhari, MD, PhD.

Role: primary

movementdisorders@children.harvard.edu

617-355-0097

Kathryn Yang, MD

Role: backup

movementdisorders@children.harvard.edu

References

Camfield P, Camfield C. Incidence, prevalence and aetiology of seizures and epilepsy in children. Epileptic Disord. 2015 Jun;17(2):117-23. doi: 10.1684/epd.2015.0736.

Reference Type: BACKGROUND

PMID: 25895502 (View on PubMed)

Zesiewicz TA, Sullivan KL, Hauser RA. Levodopa-induced dyskinesia in Parkinson's disease: epidemiology, etiology, and treatment. Curr Neurol Neurosci Rep. 2007 Jul;7(4):302-10. doi: 10.1007/s11910-007-0046-y.

Reference Type: BACKGROUND

PMID: 17618536 (View on PubMed)

Kwan P, Arzimanoglou A, Berg AT, Brodie MJ, Allen Hauser W, Mathern G, Moshe SL, Perucca E, Wiebe S, French J. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia. 2010 Jun;51(6):1069-77. doi: 10.1111/j.1528-1167.2009.02397.x. Epub 2009 Nov 3.

Reference Type: BACKGROUND

PMID: 19889013 (View on PubMed)

Russ SA, Larson K, Halfon N. A national profile of childhood epilepsy and seizure disorder. Pediatrics. 2012 Feb;129(2):256-64. doi: 10.1542/peds.2010-1371. Epub 2012 Jan 23.

Reference Type: BACKGROUND

PMID: 22271699 (View on PubMed)

Sillanpaa M. Long-term outcome of epilepsy. Epileptic Disord. 2000 Jun;2(2):79-88.

Reference Type: BACKGROUND

PMID: 10954238 (View on PubMed)

Vasconcellos E, Wyllie E, Sullivan S, Stanford L, Bulacio J, Kotagal P, Bingaman W. Mental retardation in pediatric candidates for epilepsy surgery: the role of early seizure onset. Epilepsia. 2001 Feb;42(2):268-74. doi: 10.1046/j.1528-1157.2001.12200.x.

Reference Type: BACKGROUND

PMID: 11240601 (View on PubMed)

Wendorff J. [Epilepsy and mental retardation. The school's functioning in children with epilepsy]. Przegl Lek. 2010;67(11):1175-8. Polish.

Reference Type: BACKGROUND

PMID: 21442972 (View on PubMed)

Thompson R, Kerr M, Glynn M, Linehan C. Caring for a family member with intellectual disability and epilepsy: practical, social and emotional perspectives. Seizure. 2014 Nov;23(10):856-63. doi: 10.1016/j.seizure.2014.07.005. Epub 2014 Jul 19.

Reference Type: BACKGROUND

PMID: 25086700 (View on PubMed)

Sanger TD, Chen D, Fehlings DL, Hallett M, Lang AE, Mink JW, Singer HS, Alter K, Ben-Pazi H, Butler EE, Chen R, Collins A, Dayanidhi S, Forssberg H, Fowler E, Gilbert DL, Gorman SL, Gormley ME Jr, Jinnah HA, Kornblau B, Krosschell KJ, Lehman RK, MacKinnon C, Malanga CJ, Mesterman R, Michaels MB, Pearson TS, Rose J, Russman BS, Sternad D, Swoboda KJ, Valero-Cuevas F. Definition and classification of hyperkinetic movements in childhood. Mov Disord. 2010 Aug 15;25(11):1538-49. doi: 10.1002/mds.23088.

Reference Type: BACKGROUND

PMID: 20589866 (View on PubMed)

van Egmond ME, Kuiper A, Eggink H, Sinke RJ, Brouwer OF, Verschuuren-Bemelmans CC, Sival DA, Tijssen MA, de Koning TJ. Dystonia in children and adolescents: a systematic review and a new diagnostic algorithm. J Neurol Neurosurg Psychiatry. 2015 Jul;86(7):774-81. doi: 10.1136/jnnp-2014-309106. Epub 2014 Nov 13.

Reference Type: BACKGROUND

PMID: 25395479 (View on PubMed)

van Egmond ME, Lugtenberg CHA, Brouwer OF, Contarino MF, Fung VSC, Heiner-Fokkema MR, van Hilten JJ, van der Hout AH, Peall KJ, Sinke RJ, Roze E, Verschuuren-Bemelmans CC, Willemsen MA, Wolf NI, Tijssen MA, de Koning TJ. A post hoc study on gene panel analysis for the diagnosis of dystonia. Mov Disord. 2017 Apr;32(4):569-575. doi: 10.1002/mds.26937. Epub 2017 Feb 10.

Reference Type: BACKGROUND

PMID: 28186668 (View on PubMed)

Martin K, Jackson CF, Levy RG, Cooper PN. Ketogenic diet and other dietary treatments for epilepsy. Cochrane Database Syst Rev. 2016 Feb 9;2:CD001903. doi: 10.1002/14651858.CD001903.pub3.

Reference Type: BACKGROUND

PMID: 26859528 (View on PubMed)

Cunha JM, Carlini EA, Pereira AE, Ramos OL, Pimentel C, Gagliardi R, Sanvito WL, Lander N, Mechoulam R. Chronic administration of cannabidiol to healthy volunteers and epileptic patients. Pharmacology. 1980;21(3):175-85. doi: 10.1159/000137430.

Reference Type: BACKGROUND

PMID: 7413719 (View on PubMed)

Mechoulam R, Carlini EA. Toward drugs derived from cannabis. Naturwissenschaften. 1978 Apr;65(4):174-9. doi: 10.1007/BF00450585.

Reference Type: BACKGROUND

PMID: 351429 (View on PubMed)

Devinsky O, Marsh E, Friedman D, Thiele E, Laux L, Sullivan J, Miller I, Flamini R, Wilfong A, Filloux F, Wong M, Tilton N, Bruno P, Bluvstein J, Hedlund J, Kamens R, Maclean J, Nangia S, Singhal NS, Wilson CA, Patel A, Cilio MR. Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial. Lancet Neurol. 2016 Mar;15(3):270-8. doi: 10.1016/S1474-4422(15)00379-8. Epub 2015 Dec 24.

Reference Type: BACKGROUND

PMID: 26724101 (View on PubMed)

Fish DR, Smith SJ, Quesney LF, Andermann F, Rasmussen T. Surgical treatment of children with medically intractable frontal or temporal lobe epilepsy: results and highlights of 40 years' experience. Epilepsia. 1993 Mar-Apr;34(2):244-7. doi: 10.1111/j.1528-1157.1993.tb02405.x.

Reference Type: BACKGROUND

PMID: 8453932 (View on PubMed)

Paolicchi JM, Jayakar P, Dean P, Yaylali I, Morrison G, Prats A, Resnik T, Alvarez L, Duchowny M. Predictors of outcome in pediatric epilepsy surgery. Neurology. 2000 Feb 8;54(3):642-7. doi: 10.1212/wnl.54.3.642.

Reference Type: BACKGROUND

PMID: 10680797 (View on PubMed)

Wyllie E. Surgical treatment of epilepsy in pediatric patients. Can J Neurol Sci. 2000 May;27(2):106-10.

Reference Type: BACKGROUND

PMID: 10830341 (View on PubMed)

Harkness W. Temporal lobe resections. Childs Nerv Syst. 2006 Aug;22(8):936-44. doi: 10.1007/s00381-006-0140-5. Epub 2006 Jul 11.

Reference Type: BACKGROUND

PMID: 16832669 (View on PubMed)

Freitag H, Tuxhorn I. Cognitive function in preschool children after epilepsy surgery: rationale for early intervention. Epilepsia. 2005 Apr;46(4):561-7. doi: 10.1111/j.0013-9580.2005.03504.x.

Reference Type: BACKGROUND

PMID: 15816951 (View on PubMed)

Leiphart JW, Peacock WJ, Mathern GW. Lobar and multilobar resections for medically intractable pediatric epilepsy. Pediatr Neurosurg. 2001 Jun;34(6):311-8. doi: 10.1159/000056044.

Reference Type: BACKGROUND

PMID: 11455232 (View on PubMed)

Cossu M, Lo Russo G, Francione S, Mai R, Nobili L, Sartori I, Tassi L, Citterio A, Colombo N, Bramerio M, Galli C, Castana L, Cardinale F. Epilepsy surgery in children: results and predictors of outcome on seizures. Epilepsia. 2008 Jan;49(1):65-72. doi: 10.1111/j.1528-1167.2007.01207.x. Epub 2007 Jul 21.

Reference Type: BACKGROUND

PMID: 17645538 (View on PubMed)

Maehara T, Shimizu H, Kawai K, Shigetomo R, Tamagawa K, Yamada T, Inoue M. Postoperative development of children after hemispherotomy. Brain Dev. 2002 Apr;24(3):155-60. doi: 10.1016/s0387-7604(02)00010-4.

Reference Type: BACKGROUND

PMID: 11934511 (View on PubMed)

Shimizu H. Our experience with pediatric epilepsy surgery focusing on corpus callosotomy and hemispherotomy. Epilepsia. 2005;46 Suppl 1:30-1. doi: 10.1111/j.0013-9580.2005.461009.x.

Reference Type: BACKGROUND

PMID: 15816976 (View on PubMed)

Basheer SN, Connolly MB, Lautzenhiser A, Sherman EM, Hendson G, Steinbok P. Hemispheric surgery in children with refractory epilepsy: seizure outcome, complications, and adaptive function. Epilepsia. 2007 Jan;48(1):133-40. doi: 10.1111/j.1528-1167.2006.00909.x.

Reference Type: BACKGROUND

PMID: 17241220 (View on PubMed)

Gonzalez-Martinez JA, Gupta A, Kotagal P, Lachhwani D, Wyllie E, Luders HO, Bingaman WE. Hemispherectomy for catastrophic epilepsy in infants. Epilepsia. 2005 Sep;46(9):1518-25. doi: 10.1111/j.1528-1167.2005.53704.x.

Reference Type: BACKGROUND

PMID: 16146448 (View on PubMed)

Graham D, Tisdall MM, Gill D. Corpus callosotomy outcomes in pediatric patients: A systematic review. Epilepsia. 2016 Jul;57(7):1053-68. doi: 10.1111/epi.13408. Epub 2016 May 29.

Reference Type: BACKGROUND

PMID: 27237542 (View on PubMed)

Hallbook T, Lundgren J, Stjernqvist K, Blennow G, Stromblad LG, Rosen I. Vagus nerve stimulation in 15 children with therapy resistant epilepsy; its impact on cognition, quality of life, behaviour and mood. Seizure. 2005 Oct;14(7):504-13. doi: 10.1016/j.seizure.2005.08.007. Epub 2005 Sep 19.

Reference Type: BACKGROUND

PMID: 16176878 (View on PubMed)

Klinkenberg S, Majoie HJ, van der Heijden MM, Rijkers K, Leenen L, Aldenkamp AP. Vagus nerve stimulation has a positive effect on mood in patients with refractory epilepsy. Clin Neurol Neurosurg. 2012 May;114(4):336-40. doi: 10.1016/j.clineuro.2011.11.016. Epub 2011 Nov 30.

Reference Type: BACKGROUND

PMID: 22130047 (View on PubMed)

Klinkenberg S, van den Bosch CN, Majoie HJ, Aalbers MW, Leenen L, Hendriksen J, Cornips EM, Rijkers K, Vles JS, Aldenkamp AP. Behavioural and cognitive effects during vagus nerve stimulation in children with intractable epilepsy - a randomized controlled trial. Eur J Paediatr Neurol. 2013 Jan;17(1):82-90. doi: 10.1016/j.ejpn.2012.07.003. Epub 2012 Aug 9.

Reference Type: BACKGROUND

PMID: 22878130 (View on PubMed)

Terra VC, Furlanetti LL, Nunes AA, Thome U, Nisyiama MA, Sakamoto AC, Machado HR. Vagus nerve stimulation in pediatric patients: Is it really worthwhile? Epilepsy Behav. 2014 Feb;31:329-33. doi: 10.1016/j.yebeh.2013.10.011. Epub 2013 Nov 5.

Reference Type: BACKGROUND

PMID: 24210463 (View on PubMed)

Klinkenberg S, Aalbers MW, Vles JS, Cornips EM, Rijkers K, Leenen L, Kessels FG, Aldenkamp AP, Majoie M. Vagus nerve stimulation in children with intractable epilepsy: a randomized controlled trial. Dev Med Child Neurol. 2012 Sep;54(9):855-61. doi: 10.1111/j.1469-8749.2012.04305.x. Epub 2012 Apr 28.

Reference Type: BACKGROUND

PMID: 22540141 (View on PubMed)

Air EL, Ostrem JL, Sanger TD, Starr PA. Deep brain stimulation in children: experience and technical pearls. J Neurosurg Pediatr. 2011 Dec;8(6):566-74. doi: 10.3171/2011.8.PEDS11153.

Reference Type: BACKGROUND

PMID: 22132914 (View on PubMed)

Haridas A, Tagliati M, Osborn I, Isaias I, Gologorsky Y, Bressman SB, Weisz D, Alterman RL. Pallidal deep brain stimulation for primary dystonia in children. Neurosurgery. 2011 Mar;68(3):738-43; discussion 743. doi: 10.1227/NEU.0b013e3182077396.

Reference Type: BACKGROUND

PMID: 21164379 (View on PubMed)

Timmermann L, Pauls KA, Wieland K, Jech R, Kurlemann G, Sharma N, Gill SS, Haenggeli CA, Hayflick SJ, Hogarth P, Leenders KL, Limousin P, Malanga CJ, Moro E, Ostrem JL, Revilla FJ, Santens P, Schnitzler A, Tisch S, Valldeoriola F, Vesper J, Volkmann J, Woitalla D, Peker S. Dystonia in neurodegeneration with brain iron accumulation: outcome of bilateral pallidal stimulation. Brain. 2010 Mar;133(Pt 3):701-12. doi: 10.1093/brain/awq022. Epub 2010 Mar 5.

Reference Type: BACKGROUND

PMID: 20207700 (View on PubMed)

Borggraefe I, Mehrkens JH, Telegravciska M, Berweck S, Botzel K, Heinen F. Bilateral pallidal stimulation in children and adolescents with primary generalized dystonia--report of six patients and literature-based analysis of predictive outcomes variables. Brain Dev. 2010 Mar;32(3):223-8. doi: 10.1016/j.braindev.2009.03.010. Epub 2009 Apr 28.

Reference Type: BACKGROUND

PMID: 19403250 (View on PubMed)

Jinnah HA, Factor SA. Diagnosis and treatment of dystonia. Neurol Clin. 2015 Feb;33(1):77-100. doi: 10.1016/j.ncl.2014.09.002.

Reference Type: BACKGROUND

PMID: 25432724 (View on PubMed)

Anderson WS, Lenz FA. Surgery insight: Deep brain stimulation for movement disorders. Nat Clin Pract Neurol. 2006 Jun;2(6):310-20. doi: 10.1038/ncpneuro0193.

Reference Type: BACKGROUND

PMID: 16932575 (View on PubMed)

DeLong M, Wichmann T. Deep brain stimulation for movement and other neurologic disorders. Ann N Y Acad Sci. 2012 Aug;1265:1-8. doi: 10.1111/j.1749-6632.2012.06608.x. Epub 2012 Jul 23.

Reference Type: BACKGROUND

PMID: 22823512 (View on PubMed)

Yu H, Neimat JS. The treatment of movement disorders by deep brain stimulation. Neurotherapeutics. 2008 Jan;5(1):26-36. doi: 10.1016/j.nurt.2007.10.072.

Reference Type: BACKGROUND

PMID: 18164481 (View on PubMed)

Borggraefe I, Boetzel K, Boehmer J, Berweck S, Mueller-Felber W, Mueller K, Mehrkens JH, Heinen F. Return to participation - significant improvement after bilateral pallidal stimulation in rapidly progressive DYT-1 dystonia. Neuropediatrics. 2008 Aug;39(4):239-42. doi: 10.1055/s-0028-1112117. Epub 2009 Jan 22.

Reference Type: BACKGROUND

PMID: 19165713 (View on PubMed)

Fisher R, Salanova V, Witt T, Worth R, Henry T, Gross R, Oommen K, Osorio I, Nazzaro J, Labar D, Kaplitt M, Sperling M, Sandok E, Neal J, Handforth A, Stern J, DeSalles A, Chung S, Shetter A, Bergen D, Bakay R, Henderson J, French J, Baltuch G, Rosenfeld W, Youkilis A, Marks W, Garcia P, Barbaro N, Fountain N, Bazil C, Goodman R, McKhann G, Babu Krishnamurthy K, Papavassiliou S, Epstein C, Pollard J, Tonder L, Grebin J, Coffey R, Graves N; SANTE Study Group. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010 May;51(5):899-908. doi: 10.1111/j.1528-1167.2010.02536.x. Epub 2010 Mar 17.

Reference Type: BACKGROUND

PMID: 20331461 (View on PubMed)

Li MCH, Cook MJ. Deep brain stimulation for drug-resistant epilepsy. Epilepsia. 2018 Feb;59(2):273-290. doi: 10.1111/epi.13964. Epub 2017 Dec 7.

Reference Type: BACKGROUND

PMID: 29218702 (View on PubMed)

Coubes P, Echenne B, Roubertie A, Vayssiere N, Tuffery S, Humbertclaude V, Cambonie G, Claustres M, Frerebeau P. [Treatment of early-onset generalized dystonia by chronic bilateral stimulation of the internal globus pallidus. Apropos of a case]. Neurochirurgie. 1999 May;45(2):139-44. French.

Reference Type: BACKGROUND

PMID: 10448655 (View on PubMed)

Valentin A, Selway RP, Amarouche M, Mundil N, Ughratdar I, Ayoubian L, Martin-Lopez D, Kazi F, Dar T, Jimenez-Jimenez D, Hughes E, Alarcon G. Intracranial stimulation for children with epilepsy. Eur J Paediatr Neurol. 2017 Jan;21(1):223-231. doi: 10.1016/j.ejpn.2016.10.011. Epub 2016 Nov 1.

Reference Type: BACKGROUND

PMID: 27840024 (View on PubMed)

Marks WA, Honeycutt J, Acosta F, Reed M. Deep brain stimulation for pediatric movement disorders. Semin Pediatr Neurol. 2009 Jun;16(2):90-8. doi: 10.1016/j.spen.2009.04.001.

Reference Type: BACKGROUND

PMID: 19501337 (View on PubMed)

Lipsman N, Ellis M, Lozano AM. Current and future indications for deep brain stimulation in pediatric populations. Neurosurg Focus. 2010 Aug;29(2):E2. doi: 10.3171/2010.5.FOCUS1095.

Reference Type: BACKGROUND

PMID: 20672919 (View on PubMed)

Yan H, Toyota E, Anderson M, Abel TJ, Donner E, Kalia SK, Drake J, Rutka JT, Ibrahim GM. A systematic review of deep brain stimulation for the treatment of drug-resistant epilepsy in childhood. J Neurosurg Pediatr. 2019 Mar 1;23(3):274-284. doi: 10.3171/2018.9.PEDS18417. Epub 2018 Nov 30.

Reference Type: BACKGROUND

PMID: 30544364 (View on PubMed)

Fisher RS, Uematsu S, Krauss GL, Cysyk BJ, McPherson R, Lesser RP, Gordon B, Schwerdt P, Rise M. Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia. 1992 Sep-Oct;33(5):841-51. doi: 10.1111/j.1528-1157.1992.tb02192.x.

Reference Type: BACKGROUND

PMID: 1396427 (View on PubMed)

Kim SH, Lim SC, Yang DW, Cho JH, Son BC, Kim J, Hong SB, Shon YM. Thalamo-cortical network underlying deep brain stimulation of centromedian thalamic nuclei in intractable epilepsy: a multimodal imaging analysis. Neuropsychiatr Dis Treat. 2017 Oct 17;13:2607-2619. doi: 10.2147/NDT.S148617. eCollection 2017.

Reference Type: BACKGROUND

PMID: 29089767 (View on PubMed)

Valentin A, Garcia Navarrete E, Chelvarajah R, Torres C, Navas M, Vico L, Torres N, Pastor J, Selway R, Sola RG, Alarcon G. Deep brain stimulation of the centromedian thalamic nucleus for the treatment of generalized and frontal epilepsies. Epilepsia. 2013 Oct;54(10):1823-33. doi: 10.1111/epi.12352. Epub 2013 Sep 13.

Reference Type: BACKGROUND

PMID: 24032641 (View on PubMed)

Velasco AL, Velasco F, Jimenez F, Velasco M, Castro G, Carrillo-Ruiz JD, Fanghanel G, Boleaga B. Neuromodulation of the centromedian thalamic nuclei in the treatment of generalized seizures and the improvement of the quality of life in patients with Lennox-Gastaut syndrome. Epilepsia. 2006 Jul;47(7):1203-12. doi: 10.1111/j.1528-1167.2006.00593.x.

Reference Type: BACKGROUND

PMID: 16886984 (View on PubMed)

Velasco F, Velasco M, Jimenez F, Velasco AL, Brito F, Rise M, Carrillo-Ruiz JD. Predictors in the treatment of difficult-to-control seizures by electrical stimulation of the centromedian thalamic nucleus. Neurosurgery. 2000 Aug;47(2):295-304; discussion 304-5. doi: 10.1097/00006123-200008000-00007.

Reference Type: BACKGROUND

PMID: 10942002 (View on PubMed)

Velasco F, Velasco M, Ogarrio C, Fanghanel G. Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia. 1987 Jul-Aug;28(4):421-30. doi: 10.1111/j.1528-1157.1987.tb03668.x.

Reference Type: BACKGROUND

PMID: 3497802 (View on PubMed)

Lin JP, Lumsden DE, Gimeno H, Kaminska M. The impact and prognosis for dystonia in childhood including dystonic cerebral palsy: a clinical and demographic tertiary cohort study. J Neurol Neurosurg Psychiatry. 2014 Nov;85(11):1239-44. doi: 10.1136/jnnp-2013-307041. Epub 2014 Mar 3.

Reference Type: BACKGROUND

PMID: 24591458 (View on PubMed)

Keen JR, Przekop A, Olaya JE, Zouros A, Hsu FP. Deep brain stimulation for the treatment of childhood dystonic cerebral palsy. J Neurosurg Pediatr. 2014 Dec;14(6):585-93. doi: 10.3171/2014.8.PEDS141. Epub 2014 Oct 17.

Reference Type: BACKGROUND

PMID: 25325412 (View on PubMed)

Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH. Deep brain stimulation for treatment-resistant depression. Neuron. 2005 Mar 3;45(5):651-60. doi: 10.1016/j.neuron.2005.02.014.

Reference Type: BACKGROUND

PMID: 15748841 (View on PubMed)

Lipsman N, Woodside DB, Giacobbe P, Hamani C, Carter JC, Norwood SJ, Sutandar K, Staab R, Elias G, Lyman CH, Smith GS, Lozano AM. Subcallosal cingulate deep brain stimulation for treatment-refractory anorexia nervosa: a phase 1 pilot trial. Lancet. 2013 Apr 20;381(9875):1361-1370. doi: 10.1016/S0140-6736(12)62188-6. Epub 2013 Mar 7.

Reference Type: BACKGROUND

PMID: 23473846 (View on PubMed)

Laxton AW, Tang-Wai DF, McAndrews MP, Zumsteg D, Wennberg R, Keren R, Wherrett J, Naglie G, Hamani C, Smith GS, Lozano AM. A phase I trial of deep brain stimulation of memory circuits in Alzheimer's disease. Ann Neurol. 2010 Oct;68(4):521-34. doi: 10.1002/ana.22089.

Reference Type: BACKGROUND

PMID: 20687206 (View on PubMed)

Andrade DM, Zumsteg D, Hamani C, Hodaie M, Sarkissian S, Lozano AM, Wennberg RA. Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology. 2006 May 23;66(10):1571-3. doi: 10.1212/01.wnl.0000206364.19772.39. Epub 2006 Mar 15.

Reference Type: BACKGROUND

PMID: 16540602 (View on PubMed)

Hung SW, Hamani C, Lozano AM, Poon YY, Piboolnurak P, Miyasaki JM, Lang AE, Dostrovsky JO, Hutchison WD, Moro E. Long-term outcome of bilateral pallidal deep brain stimulation for primary cervical dystonia. Neurology. 2007 Feb 6;68(6):457-9. doi: 10.1212/01.wnl.0000252932.71306.89.

Reference Type: BACKGROUND

PMID: 17283323 (View on PubMed)

Kumar R, Lozano AM, Montgomery E, Lang AE. Pallidotomy and deep brain stimulation of the pallidum and subthalamic nucleus in advanced Parkinson's disease. Mov Disord. 1998;13 Suppl 1:73-82.

Reference Type: BACKGROUND

PMID: 9613722 (View on PubMed)

Kumar R, Lozano AM, Sime E, Lang AE. Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremor. Neurology. 2003 Dec 9;61(11):1601-4. doi: 10.1212/01.wnl.0000096012.07360.1c.

Reference Type: BACKGROUND

PMID: 14663050 (View on PubMed)

Lozano AM, Mayberg HS, Giacobbe P, Hamani C, Craddock RC, Kennedy SH. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression. Biol Psychiatry. 2008 Sep 15;64(6):461-7. doi: 10.1016/j.biopsych.2008.05.034. Epub 2008 Jul 18.

Reference Type: BACKGROUND

PMID: 18639234 (View on PubMed)

Moro E, Lang AE, Strafella AP, Poon YY, Arango PM, Dagher A, Hutchison WD, Lozano AM. Bilateral globus pallidus stimulation for Huntington's disease. Ann Neurol. 2004 Aug;56(2):290-4. doi: 10.1002/ana.20183.

Reference Type: BACKGROUND

PMID: 15293283 (View on PubMed)

Moro E, Piboolnurak P, Arenovich T, Hung SW, Poon YY, Lozano AM. Pallidal stimulation in cervical dystonia: clinical implications of acute changes in stimulation parameters. Eur J Neurol. 2009 Apr;16(4):506-12. doi: 10.1111/j.1468-1331.2008.02520.x.

Reference Type: BACKGROUND

PMID: 19207733 (View on PubMed)

Moro E, Hamani C, Poon YY, Al-Khairallah T, Dostrovsky JO, Hutchison WD, Lozano AM. Unilateral pedunculopontine stimulation improves falls in Parkinson's disease. Brain. 2010 Jan;133(Pt 1):215-24. doi: 10.1093/brain/awp261. Epub 2009 Oct 21.

Reference Type: BACKGROUND

PMID: 19846583 (View on PubMed)

Rodriguez-Oroz MC, Obeso JA, Lang AE, Houeto JL, Pollak P, Rehncrona S, Kulisevsky J, Albanese A, Volkmann J, Hariz MI, Quinn NP, Speelman JD, Guridi J, Zamarbide I, Gironell A, Molet J, Pascual-Sedano B, Pidoux B, Bonnet AM, Agid Y, Xie J, Benabid AL, Lozano AM, Saint-Cyr J, Romito L, Contarino MF, Scerrati M, Fraix V, Van Blercom N. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up. Brain. 2005 Oct;128(Pt 10):2240-9. doi: 10.1093/brain/awh571. Epub 2005 Jun 23.

Reference Type: BACKGROUND

PMID: 15975946 (View on PubMed)

Other Identifiers

IRB-P00047069

Identifier Type: -

Identifier Source: org_study_id