Bleaching Effect of Solo and Combined Kiwi Extract and Ozone and Their Impact on Enamel

NCT ID: NCT06582069

Last Updated: 2024-09-03

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 40 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-09-01
• Study Completion Date: 2026-01-01

Brief Summary

ozone therapy has been extensively used in dentistry to manage wounds healing, dental caries, oral lichen planus, gingivitis and periodontitis, halitosis, osteonecrosis of the jaw, post-surgical pain, plaque and biofilms, root canal treatment, dentin hypersensitivity, tempro-mandibular joint disorders and teeth whitening, And based on the above, in this study kiwi extract and ozone gas will be used individually and combined to evaluate the resultant effects on bleaching, enamel microhardness and micromorphology.

Conditions

Discoloration, Tooth

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

bleaching with 2% kiwi extract.

The fresh pulpy kiwi will be bought 200 gm of kiwi fruits were cleaned, cut into round shapes and blended with 15 mL of distilled water in a blender to obtain about 50 mL of kiwi concentrate.

This concentrate will be filtered and then transferred into a cooling centrifuge to be processed at 2000 rpm for about 20 minutes at a temperature of 40°C.

The extract thus collected will be stored at 4°C till further use.

Group Type: EXPERIMENTAL

Bleaching

Intervention Type: DEVICE

Bleaching

bleaching using 2,350 ppm ozone gas.

A 2,350 ppm ozone concentration at a 615 cc per minute flow rate will be supplied by a well-known ozone producing machine.

The ppm of ozone supplied will be verified via an ozone detection device, and the ozone flow rate will be verified by a flow meter directly before the start of the experiment.

Ozone gas will be distributed to the tooth surfaces through special trays to assure a perfect seal to prevent any ozone leakage and to be safely employed to humans

Group Type: EXPERIMENTAL

Bleaching

Intervention Type: DEVICE

Bleaching

bleaching with 2% kiwi extract followed By 2,350 ppm ozone gas.

The fresh pulpy kiwi will be bought 200 gm of kiwi fruits were cleaned, cut into round shapes and blended with 15 mL of distilled water in a blender to obtain about 50 mL of kiwi concentrate.

This concentrate will be filtered and then transferred into a cooling centrifuge to be processed at 2000 rpm for about 20 minutes at a temperature of 40°C.

The extract thus collected will be stored at 4°C till further use. A 2,350 ppm ozone concentration at a 615 cc per minute flow rate will be supplied by a well-known ozone producing machine.

The ppm of ozone supplied will be verified via an ozone detection device, and the ozone flow rate will be verified by a flow meter directly before the start of the experiment.

Ozone gas will be distributed to the tooth surfaces through special trays to assure a perfect seal to prevent any ozone leakage and to be safely employed to humans.

Group Type: EXPERIMENTAL

Bleaching

Intervention Type: DEVICE

Bleaching

bleaching with 38% hydrogen peroxide.

Application of 38% H2O2 gel for 20 minutes. Then, the H2O2 gel will be removed, and teeth will be sprayed for 10 seconds with water from a 3-in-1 syringe

Group Type: EXPERIMENTAL

Bleaching

Intervention Type: DEVICE

Bleaching

Interventions

Bleaching

Bleaching

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• A total of the 40 participants aged between (18-35 years) with no gender prediction.
• The participation will be entirely voluntary, and a signed statement of informed consent will be obtained prior to the start of the study.
• Systemically healthy subject based on medical and drug histories, a subject requiring scaling and polishing with moderate calculus with at least two non-adjacent hypersensitive teeth with Schiff scale scores >1 with air blast stimulus.
• Access to sound maxillary anterior teeth.
• Vitapan classical shades should be A3 or darker and lighter shades are not included.

Exclusion Criteria

• Participants with poor oral hygiene.
• Participants with missing anterior teeth.
• Participants with unrealistic expectations.
• Participants with dental caries, those undergoing orthodontic treatment.
• Participants with a history of periodontal treatment, pregnant or lactating women and individuals with a history of asthma.
• Those who are allergic to kiwi or ozone skin therapy were excluded from the study.
• Smokers are excluded from the present study.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Al-Azhar University

OTHER

Sponsor Role: lead

Responsible Party

Mona Bedier El Lakanay

Teaching Assistant

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

24/3/2024

Identifier Type: -

Identifier Source: org_study_id