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Bleaching Effect of Strawberry Extract Versus Hydrogen Peroxide in Patients With Extrinsic Staining

NCT ID: NCT06287060

Last Updated: 2024-02-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-07-31

Study Completion Date

2024-12-31

Brief Summary

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with limited evidence based information in literature about using Strawberry extract for teeth bleaching in patients with extrinsic staining , it is beneficial to evaluate this new material using a randomized controlled clinical trial to test the null hypothesis that this extract will have the same effect as Hydrogen peroxide regarding the bleaching effect and hypersensitivity.

Detailed Description

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The whitening effect of strawberry is due to the presence of malic acid, which acts as a natural astringent to remove surface discoloration. The ellagic acid content in strawberry is ranging from 0.43 to 4.64 mg/g dry weight. The more amount of ellagic acid will produce more potential OH clusters as a powerful oxidizer thus make the more effective bleaching process. Ellagic acid releases the OH and H radicals which will react with the tooth enamel organic molecules and disrupt the electron conjugation, as well as changing the energy absorption in the tooth enamel organic molecules to form smaller organic molecules with a lighter color. Ellagic acid has an OH cluster, not COOH cluster like any other acids. The electronegativity of the OH group will be easier to break and react with the organic molecules of tooth enamel.

Conditions

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Bleaching Effect and Postoperative Sensitivity of Strawberry Extract

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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patients with extrinsic staining will be treated with strawberry extract.

Group Type EXPERIMENTAL

strawberry extract.

Intervention Type OTHER

strawberry has a whitening effect due to its content of ellagic and maleic acids. the presence of acidic components namely ascorbic acid may increase the surface energy by removing the surface debris, thereby allowing the citric and maleic acids to penetrate into tooth surface to remove the surface stains.

patients with extrinsic staining will be treated with Hydrogen peroxide bleaching agent.

Group Type ACTIVE_COMPARATOR

strawberry extract.

Intervention Type OTHER

strawberry has a whitening effect due to its content of ellagic and maleic acids. the presence of acidic components namely ascorbic acid may increase the surface energy by removing the surface debris, thereby allowing the citric and maleic acids to penetrate into tooth surface to remove the surface stains.

Interventions

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strawberry extract.

strawberry has a whitening effect due to its content of ellagic and maleic acids. the presence of acidic components namely ascorbic acid may increase the surface energy by removing the surface debris, thereby allowing the citric and maleic acids to penetrate into tooth surface to remove the surface stains.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. At least 18 years old.
2. Good general and oral health.
3. six present maxillary anterior teeth.


1. yellowing of teeth due to age.
2. stains due to coffee or tea.
3. light tetracycline stain.

Exclusion Criteria

1. patients undergoing radiotherapy or chemotherapy.
2. Pregnant females or breast feeders.
3. Bruxism and patients who reported tooth sensitivity.


1. Hypoplastic enamel.
2. carious lesion.
3. sensitive recession area or sensitive tooth.
4. Amalgam staining.
5. Non vital tooth.
6. Discolration due to pulp trauma or necrosis.
7. presence of non carious cervical lesion.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cairo University

OTHER

Sponsor Role lead

Responsible Party

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Randa Khaled Mostafa

principle investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Other Identifiers

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Strawberry extract

Identifier Type: -

Identifier Source: org_study_id