The Study to Evaluate the Safety and Efficacy of the Onyx Family

NCT ID: NCT06577896

Last Updated: 2024-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-06-09

Study Completion Date

2026-12-31

Brief Summary

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Observation of the safety and efficacy of 1-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention using Onyx family stents in elderly patients aged 75 years or older

Detailed Description

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For elderly patients aged 75 years or older undergoing percutaneous coronary intervention with Onyx family drug-eluting stents, observe the safety and efficacy of transitioning from dual antiplatelet therapy to single therapy for one year after one month of dual antiplatelet therapy

Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Aged 75 or more

Elderly patients aged 75 years or older

Onyx family

Intervention Type DEVICE

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Eligible for interventional procedures

"Patients requiring PCI (Percutaneous Coronary Intervention) procedure

Onyx family

Intervention Type DEVICE

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Evidence of myocardial ischemia or coronary artery stenosis ≥ 50%

Patients with evidence of myocardial ischemia or coronary artery stenosis ≥ 50% on coronary angiography

Onyx family

Intervention Type DEVICE

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Able to take antiplatelets for at least 1 months after the procedure

Patients able to take antiplatelets after the procedure

Onyx family

Intervention Type DEVICE

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Patients who underwent coronary artery procedures with ZES stent

Patients who underwent coronary artery procedures with Onyx™ family stent

Onyx family

Intervention Type DEVICE

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Interventions

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Onyx family

Safety and Efficacy of 1-Month DAPT in Elderly Patients at High Risk of Ischemia and Bleeding After Percutaneous Coronary Intervention with Onyx Family Stents

Intervention Type DEVICE

Other Intervention Names

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Onyx frontier Resolute Onyx

Eligibility Criteria

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Inclusion Criteria

* Aged 75 or more.
* Eligible for interventional procedures.
* Evidence of myocardial ischemia or coronary artery stenosis ≥ 50%.
* Able to take antiplatelets for at least 1 months after the procedure.
* Patients who underwent coronary artery procedures with ZES (Medtronic, Minneapolis, MN, Onyx™ family) stent.

Exclusion Criteria

* The patient has a known hypersensitivity or contraindication to any of the following medications: heparin, aspirin, clopidogrel, zotarolimus, and contrast media (patients with documented sensitivity to contrast media which can be effectively premedicated with steroids and diphenhydramine \[eg, rash\] may be enrolled. Those with true anaphylaxis to prior contrast media, however, should not be enrolled).
* Patients with active pathologic bleeding.
* Gastrointestinal or genitourinary bleeding within the prior 3 months, or major surgery within 2 months.
* History of bleeding diathesis or known coagulopathy (including heparin-induced thrombocytopenia).
* Noncardiac comorbid conditions are present with life expectancy \<1 year or that may result in protocol noncompliance (per site investigator\'s medical judgment).
* Patients who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period.
Minimum Eligible Age

75 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pusan National University Yangsan Hospital

OTHER

Sponsor Role lead

Responsible Party

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Min Ku Chon

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Min Ku Chon, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Pusan National University Yangsan Hospital

Locations

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Pusan National University Yangsan Hospital

Yangsan, Gyeongsangnam-do, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Min Ku Chon, MD,PhD

Role: CONTACT

82-10-2562-6258

Facility Contacts

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Min Ku Chon, MD,PhD

Role: primary

82-10-2562-6258

Other Identifiers

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BRONYX STUDY

Identifier Type: -

Identifier Source: org_study_id

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