DYNAMic Renal Assessment: NOvel Methods to Assess KIDNEY Functional Reserve
NCT ID: NCT06572215
Last Updated: 2024-08-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
44 participants
OBSERVATIONAL
2023-12-14
2025-01-01
Brief Summary
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Detailed Description
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GFR like many other physiological processes is not static and augments temporarily to stimuli such as exercise and protein intake, by up to 25% from baseline in healthy individuals.\[3\] Similar to cardiac function stress tests which predict adverse outcomes, inability to respond to renal stressors or 'reduced renal reserve' has been demonstrated to occur prior to development of CKD (e.g. in patients with diabetes and previous acute kidney injury (AKI)) and is associated with vulnerability to future AKI, despite the presence of apparently normal kidney function measured by serum creatinine concentration.\[4\] Renal reserve is lost with progressive CKD,\[4\] and has also been demonstrated to relate to severity of histological lesions.\[5\]
Current measurements of renal reserve (stimulated increase in GFR due to augmented renal blood flow above basal fasting values) involve administration of a compound that is freely filtered by the glomerulus, unaffected by tubular function and is physiologically inert, with assessment before and after an oral protein load or amino acid infusion which induces arterial vasodilation, increasing renal blood flow and GFR
The study proposes a comparison of two novel methods of 'dynamic renal function testing' with renal reserve testing.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Healthy Participants
Dapagliflozin
On Day 3 to 16, participants will take 10mg dapaglifozin (SGLT-2 inhibitor) orally once daily.
Patients with hyperfiltration
Dapagliflozin
On Day 3 to 16, participants will take 10mg dapaglifozin (SGLT-2 inhibitor) orally once daily.
Interventions
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Dapagliflozin
On Day 3 to 16, participants will take 10mg dapaglifozin (SGLT-2 inhibitor) orally once daily.
Eligibility Criteria
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Inclusion Criteria
Exclusion:
Aged \< 40 Unable or unwilling to provide informed consent Breastfeeding or pregnant women Patients involved in other interventional research studies.
40 Years
ALL
Yes
Sponsors
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King's College London
OTHER
King's College Hospital NHS Trust
OTHER
Responsible Party
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Locations
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King's College Hospital
London, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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KCH23-128
Identifier Type: -
Identifier Source: org_study_id
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