Characteristics and Outcomes of Acute Myeloid Leukemia (AML) Patients Treated With Oral-Azacitidine Maintenance Therapy in France

NCT ID: NCT06565975

Last Updated: 2024-08-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

112 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-05-23

Study Completion Date

2024-10-31

Brief Summary

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The purpose of this study is to collect and evaluate real-world data to describe the outcomes, patient characteristics, safety profile and treatment patterns of oral azacitidine prescribed as maintenance treatment after frontline treatment or second remission for acute myeloid leukemia in France.

Detailed Description

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Conditions

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Acute Myeloid Leukemia (AML)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Participants that received maintenance treatment of oral azacitidine

Oral azacitidine

Intervention Type DRUG

As per product label, prescribed by treating physician

Interventions

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Oral azacitidine

As per product label, prescribed by treating physician

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Participants who initiated oral azacitidine maintenance therapy during early access program (EAP) in France (January 29, 2021 to July 13, 2022) or during the 6 months post-EAP (from July 14, 2022, to January 2014, 2023) inside the marketing authorization label "adult patients with acute myeloid leukaemia (AML) who achieved complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following induction therapy with or without consolidation treatment and who are not candidates for, including those who choose not to proceed to, hematopoietic stem cell transplantation (HSCT)."
* Participants with histologically confirmed diagnosis of de novo AML, or therapy-related AML, or secondary AML
* Participants who received frontline treatment after diagnosis of AML and achieved complete remission (CR), CR with incomplete blood count recovery (Cri), or CR with partial hematology recovery (CRh) after one or subsequent lines of therapy in case of relapse
* Participant is at least 18 years of age at the time of initial diagnosis of AML
* Participants alive or deceased at the time of data collection
* Physician has access to the complete medical record for the patient, including any transferred records from other facilities (if applicable); patient's medical record must at least include the following:

* Date of diagnosis of AML
* Frontline therapy(ies) received, and treatment start dates
* Date(s) of first documented evidence of response
* Oral azacitidine start and (if applicable) stop date
* Documentation (yes/no) of relapse on oral azacitidine, where applicable
* Participants who do not object to the data collection

Exclusion Criteria

* Participants who initiated maintenance with oral azacitidine after January 14, 2023
* Participant who initiated maintenance with oral azacitidine before January 14, 2023, outside of the marketing authorization label
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bristol-Myers Squibb

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bristol-Myers Squibb

Role: STUDY_DIRECTOR

Bristol-Myers Squibb

Locations

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Kappa Sante

Paris, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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CA055-1047

Identifier Type: -

Identifier Source: org_study_id

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