fMRI Accelerated TMS Depression

NCT ID: NCT06562153

Last Updated: 2025-10-16

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 20 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-09-23
• Study Completion Date: 2026-08-05

Brief Summary

This study aims to investigate whether phenotypic-related brain states revealed by a novel INSCAPE ("Individualized Network-based Single-frame Coactivation Pattern Estimation") neuroimaging method in Major Depressive Disorder (MDD) patients can track brain recovery of MDD patients over an accelerated antidepressant transcranial magnetic stimulation (TMS) treatment.

Detailed Description

The aim of this study is to use magnetic resonance imaging (MRI) to capture images of participants' brains and apply an image processing method called INSCAPE to assess brain states. This study will recruit participants who are scheduled to receive accelerated Transcranial Magnetic Stimulation (TMS) therapy for Major Depressive Disorder (MDD). Participation in this study involves two visits, each including a 30-minute MRI scan. The interval between each visit is about one week. Depressed participants will also complete mood assessments at various intervals while they are receiving accelerated TMS for depression.

Conditions

Depression

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Volunteer Participants with Major Depressive Disorders (MDD)

20 patients with MDD receiving 5-day accelerated transcranial magnetic stimulation therapy (TMS) from the clinic will be recruited to participate in this observational neuroimaging study. Participants will undergo two fMRI scans at baseline and post-treatment.

Neuroimaging with Magnetic Resonance Imaging (MRI)

Intervention Type: OTHER

MRI will be used to observe brain states over time.

Interventions

Neuroimaging with Magnetic Resonance Imaging (MRI)

MRI will be used to observe brain states over time.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age 18-65
• Have the capacity and ability to provide one's own consent in English and sign the informed consent document.
• DSM-IV diagnosis of MDD

Exclusion Criteria

• Unable to speak English.
• Contraindicated for MRI.
• Any current or recent untreated medical, neurological, or psychiatric conditions
• Metal implant devices in the head, heart, or neck.
• History of brain surgery.
• History of cortisol medication use or electroconvulsive therapy.
• Comorbidity with other psychiatric/neurological illnesses or personality disorders
• History of myocardial infarction or arrhythmia, bradycardia.
• Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
• Individuals suffering from frequent/severe headaches.
• Moderate to severe alcohol or substance use disorder.
• Pregnancy

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Foundation for the Advancement of Clinical TMS

UNKNOWN

Sponsor Role: collaborator

Medical University of South Carolina

OTHER

Sponsor Role: lead

Responsible Party

Xiaolong Peng

Research Instructor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Xiaolong Peng

Role: PRINCIPAL_INVESTIGATOR

Medical University of South Carolina

Locations

30 Bee Street

Charleston, South Carolina, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Marion Wood

Role: CONTACT

woodma@musc.edu

843-792-9502

Facility Contacts

Marion Wood

Role: primary

woodma@musc.edu

8437928502

Other Identifiers

Pro00138260

Identifier Type: -

Identifier Source: org_study_id