Association of Helicobacter Pylori Infection and Migraine
NCT ID: NCT06558578
Last Updated: 2024-08-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
50 participants
INTERVENTIONAL
2024-08-01
2025-08-30
Brief Summary
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Detailed Description
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Migraine is a complex neurovascular condition involving vasodilatation of intracranial and extracerebral blood vessels. This results in activation of trigeminal sensory nervous pain pathway leading to headache. Serotonin and reserpine (serotonin evacuator) play a notable role in the development of migraine headache by increasing cerebral blood flow.
Migraine is characterized by episodic attack that may be moderate to severe in intensity, focal in nature, have a throbbing quality. Compared to adults, pediatric migraine is shorter in duration and often has bilateral, bifrontal in the point of location.
Migraine is divided into two main types of migraine are: migraine with aura in which patients experience transient visual or sensory symptoms (including flickering lights, spots, or pins that develop 5-20 minutes before attacks), occurring in approximately 25% of patients with migraine, and migraine without aura, occurring in the remaining 75% of patients .
Helicobacter pylori infection is a significant risk factor for migraine with no observational difference between two types (migraine with and without aura). Eradication treatment was helpful on the clinical improvement of pain.
H. pylori is a gram-negative, microaerophilic, spiral bacterium with increased motility by multiple unipolar flagella. It generates urease and colonizes the mucus layer adjacent to the gastric mucosa, usually being responsible for gastrointestinal impairments such as chronic active gastroenteritis, infection, gastric and duodenal ulcer, and, more rarely, stomach cancer, also may be the result of various extra-digestive conditions such as neurological, cardiovascular, metabolic, hematologic, ocular, or dermatological ones.
A research explained that gastrointestinal neuroendocrine cells such as enterochromaffin cells (EC cells) can synthesize and secrete serotonin (5-hydroxytryptamine; 5-HT) and some factors that motivate the cell to secrete 5-HT can cause central nervous system (CNS) perturbation via the brain-gut axis. Inflammation motivates the cell to secrete 5-HT e.g., when H. pylori infect a cell. Eradication of H. pylori infection has helpful outcomes to improve clinical attacks by the effect of eradication therapy on the inflammation induced high levels of 5-HT .
Other theory suggests that during the infection, superoxide radicals and NO are produced and prolonged oxidative injury caused by the persistent infection might be involved in regional cerebral flow changes during migraine .
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
SINGLE
Study Groups
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Cases
Children with migraine (cases) Inclusion criteria Age: children between 6 and 16 years old. Both sexes. children who suffering from migraine.
Exclusion criteria:
Age: children below 6 years old\& children above 16 years old. Children suffering from epilepsy, Mental retardation, autism, attention deficient hyperactivity disorder.
Helicobacter pylori antigen in stool
H pylori antigen in stool: for all patients suffering from migraine and control group.
Upper GIT endoscopy: for children with positive H Pylori antigen in stool.
Control
Healthy children (control) healthy children not suffering from migraine or any neurological diseases.
Helicobacter pylori antigen in stool
H pylori antigen in stool: for all patients suffering from migraine and control group.
Upper GIT endoscopy: for children with positive H Pylori antigen in stool.
Interventions
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Helicobacter pylori antigen in stool
H pylori antigen in stool: for all patients suffering from migraine and control group.
Upper GIT endoscopy: for children with positive H Pylori antigen in stool.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
-Exclusion Criteria: children below 6 years old\& children above 16 years old. Children suffering from epilepsy, Mental retardation, autism, attention deficient hyperactivity disorder.
6 Years
16 Years
ALL
Yes
Sponsors
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Sohag University
OTHER
Responsible Party
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Mohamed Ragab Ali
Principal investigator
Principal Investigators
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mohamed ragab
Role: PRINCIPAL_INVESTIGATOR
Mohamed Ragab
Locations
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Faculty of medicine sohag university
Sohag, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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soh-Med-27-07-14MS
Identifier Type: -
Identifier Source: org_study_id
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